Risperidone and Reglan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Risperidone (risperidone) and Reglan (metoclopramide hydrochloride). Common drug interactions include vomiting among females and weight increased among males.

The phase IV clinical study analyzes what interactions people have when they take Risperidone and Reglan. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Risperidone?

Risperidone has active ingredients of risperidone. It is often used in bipolar disorder. eHealthMe is studying from 72,175 Risperidone users. Check the latest studies of Risperidone.

What is Reglan?

Reglan has active ingredients of metoclopramide hydrochloride. It is often used in gastroparesis. eHealthMe is studying from 29,455 Reglan users. Check the latest studies of Reglan.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

64 people who take Risperidone and Reglan together, and have interactions are studied.

Risperidone and Reglan drug interactions.

What are the common drug interactions of Risperidone and Reglan, by gender? *:

female:

Vomiting
Anaemia (lack of blood)
Anxiety
Ascites (accumulation of fluid in the abdominal cavity)
Blood pressure fluctuation
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Eating disorder
General physical health deterioration (weak health status)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

male:

Weight increased
Arthralgia (joint pain)
Urinary tract infection
Cardiac failure congestive
Hypotension (abnormally low blood pressure)
Pleural effusion (water on the lungs)
Thrombocytopenia (decrease of platelets in blood)
Abdominal pain
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Chronic kidney disease

What are the common drug interactions of Risperidone and Reglan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Cardiac disorder
Dyspnoea (difficult or laboured respiration)
Left ventricular hypertrophy (the thickening of the myocardium (muscle) of the left ventricle of the heart)
Oxygen saturation decreased
Pneumonia
Pyrexia (fever)
Rhinovirus infection
Urinary tract infection
Electrolyte imbalance

20-29:

Blood pressure decreased
Eating disorder
Fatigue (feeling of tiredness)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
General physical health deterioration (weak health status)
Infusion related reaction
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain
Panic attack
Weight decreased

30-39:

Arthralgia (joint pain)
Compulsive shopping
Eating disorder
Hospitalisation
Nephrolithiasis (calculi in the kidneys)
Weight increased
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Pancreatitis chronic (chronic inflammation of pancreas)

40-49:

Arthralgia (joint pain)
Bone disorder
Dry skin
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Hypoaesthesia (reduced sense of touch or sensation)
Injury
Malaise (a feeling of general discomfort or uneasiness)
Myalgia (muscle pain)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Merycism (a rare disease in which food is chewed, swallowed, and then returned to the mouth and chewed again)
Muscle spasms (muscle contraction)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Nail infection
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Onychomycosis (fungal infection of the nail)
Pancreatitis (inflammation of pancreas)
Periodic limb movement disorder

60+:

Drug hypersensitivity
Pleural effusion (water on the lungs)
Vomiting
Abdominal pain
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood pressure decreased
Blood pressure fluctuation
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

What are the existing conditions these people have? *

Pain: 8 people, 12.50%
Nausea (feeling of having an urge to vomit): 7 people, 10.94%
Stress And Anxiety: 6 people, 9.38%
High Blood Cholesterol: 6 people, 9.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 9.38%
Depression: 5 people, 7.81%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 4 people, 6.25%
Inflammation: 4 people, 6.25%
Infection: 4 people, 6.25%
Hypersensitivity: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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