Rituxan and Nucynta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rituxan (rituximab) and Nucynta (tapentadol hydrochloride). Common drug interactions include pharyngitis streptococcal among females and vomiting among males.

The phase IV clinical study analyzes what interactions people have when they take Rituxan and Nucynta. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Rituxan?

Rituxan has active ingredients of rituximab. It is often used in rheumatoid arthritis. eHealthMe is studying from 64,791 Rituxan users. Check the latest studies of Rituxan.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

On Jul, 12, 2026

38 people who take Rituxan and Nucynta together, and have interactions are studied.

What are the common drug interactions of Rituxan and Nucynta, by gender? *:

female:

Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Asthma
Postoperative wound infection
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Vessel puncture site bruise
Migraine (headache)
Blood pressure diastolic increased
Weight increased
Hyperhidrosis (abnormally increased sweating)
Depression

male:

Vomiting
Dizziness
Chest pain
Injection site bruising
Drug ineffective
Weight increased
Adjustment disorder with depressed mood
Adverse drug reaction
Anxiety
Arthralgia (joint pain)

What are the common drug interactions of Rituxan and Nucynta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cat scratch disease (bacterial infection by cat scratch)
Coma (state of unconsciousness lasting more than six hours)
Constipation
Cyclic vomiting syndrome (prolonged episodes of severe nausea, vomiting)
Drug ineffective
Dyskinesia (abnormality or impairment of voluntary movement)
Hyposmia (impairment of the sense of smell)
Impaired gastric emptying
Increased appetite
Memory impairment

30-39:

Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dizziness
Drug ineffective
Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Food poisoning (poison in food)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Heart rate increased
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

40-49:

Anxiety
Bone density decreased
Crying
Dehydration (dryness resulting from the removal of water)
Depression
Dizziness
Drug ineffective
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Inflammation
Nausea (feeling of having an urge to vomit)

50-59:

Vomiting
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Sensory loss (senses loss)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)

60+:

Dizziness
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure congestive
Chills (felling of cold)
Dyspnoea exertional (breathlessness or shortness of breath)
Ejection fraction decreased (systolic heart failure)
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Hyperhidrosis (abnormally increased sweating)
Hypertension (high blood pressure)

What are the existing conditions these people have? *

Sleep Disorder: 16 people, 42.11%
Thyroid Diseases: 14 people, 36.84%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 26.32%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 26.32%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 10.53%
Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 2 people, 5.26%
Hypersensitivity: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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