Rituxan and Provigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rituxan (rituximab) and Provigil (modafinil). Common drug interactions include constipation among females and memory impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Rituxan and Provigil. It is created by eHealthMe based on reports of 72 people who take the same drugs from the FDA, and is updated regularly.

What is Rituxan?

Rituxan has active ingredients of rituximab. It is often used in rheumatoid arthritis. eHealthMe is studying from 64,791 Rituxan users. Check the latest studies of Rituxan.

What is Provigil?

Provigil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 25,230 Provigil users. Check the latest studies of Provigil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

72 people who take Rituxan and Provigil together, and have interactions are studied.

What are the common drug interactions of Rituxan and Provigil, by gender? *:

female:

Constipation
Depression
Fall
Fibromyalgia (a long-term condition which causes pain all over the body)
Genital herpes (herpes infection of genital)
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)
Immune system disorder
Inflammation

male:

Memory impairment
Non-hodgkin's lymphoma recurrent (reoccurrence malignant (cancer) cells form in the lymph system)
Decreased appetite
Diabetes mellitus inadequate control
Disease recurrence
Dyspnoea exertional (breathlessness or shortness of breath)
Ear infection
Fall
Febrile neutropenia (fever with reduced white blood cells)
Haemoglobin decreased

What are the common drug interactions of Rituxan and Provigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Alopecia (absence of hair from areas of the body)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Drug ineffective
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Optic neuritis (optic nerve inflammation)
Primary progressive multiple sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged)
Progressive relapsing multiple sclerosis (chronic autoimmune disease of the central nervous system in which gradual destruction of myelin occurs in patches throughout the brain or spinal cord or both)
Relapsing-remitting multiple sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged)
Secondary progressive multiple sclerosis (a stage of ms which comes after relapsing remitting ms in many cases)

30-39:

B-lymphocyte count decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Conjunctivitis (pink eye)
Fall
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Headache (pain in head)
Herpes zoster
Kidney infection
Migraine (headache)
Muscular weakness (muscle weakness)

40-49:

Herpes zoster
Dizziness
Balance disorder
Blood folate decreased
Breast cyst
Chest discomfort
Decreased appetite
Discomfort
Dyspnoea (difficult or laboured respiration)
Dysstasia (difficulty in standing)

50-59:

Culture urine positive
Dehydration (dryness resulting from the removal of water)
Gait disturbance
Headache (pain in head)
Hip arthroplasty
Hypertension (high blood pressure)
Influenza like illness
Infusion related reaction
Jc virus test positive
Joint stiffness

60+:

Interstitial lung disease
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Adverse drug reaction
Depression
Fall
Febrile neutropenia (fever with reduced white blood cells)
Gait disturbance
Genital herpes (herpes infection of genital)
Glioblastoma (most common and most aggressive malignant primary brain tumour in humans)
Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 23 people, 31.94%
Fatigue (feeling of tiredness): 8 people, 11.11%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 6 people, 8.33%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 6.94%
Muscle Spasms (muscle contraction): 5 people, 6.94%
Gait Disturbance: 5 people, 6.94%
Primary Progressive Multiple Sclerosis (primary progressive inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 5.56%
Nausea (feeling of having an urge to vomit): 4 people, 5.56%
Immunodeficiency Common Variable: 4 people, 5.56%
Hypersensitivity: 4 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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