Rituxan and Zoledronic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rituxan (rituximab) and Zoledronic (zoledronic acid). Common drug interactions include mouth ulceration among females and alanine aminotransferase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Rituxan and Zoledronic. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Rituxan?

Rituxan has active ingredients of rituximab. It is often used in rheumatoid arthritis. eHealthMe is studying from 64,791 Rituxan users. Check the latest studies of Rituxan.

What is Zoledronic?

Zoledronic has active ingredients of zoledronic acid. eHealthMe is studying from 29,812 Zoledronic users. Check the latest studies of Zoledronic.

On Jul, 15, 2026

29 people who take Rituxan and Zoledronic together, and have interactions are studied.

Rituxan and Zoledronic drug interactions.

What are the common drug interactions of Rituxan and Zoledronic, by gender? *:

female:

Mouth ulceration (mouth ulcers)
Myalgia (muscle pain)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Papule
Rheumatoid factor
Seborrhoeic keratosis (noncancerous (benign) skin growths that some people develop as they age. they often appear on the back or chest)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)

male:

Alanine aminotransferase increased
Arthralgia (joint pain)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Hot flush (sudden feelings of heat)
Infusion related reaction
Injection site extravasation (flow of (blood or lymph) from injection site)
Oedema peripheral (superficial swelling)
Oxygen saturation decreased
Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)

What are the common drug interactions of Rituxan and Zoledronic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiac arrest

50-59:

Abdominal pain
Antinuclear antibody positive
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Arthropathy
Asthma
Back disorder
Blood immunoglobulin g decreased
Blood immunoglobulin m decreased
Body tinea (ringworm of the body)
Colitis (inflammation of colon)

60+:

Heart rate increased
Oxygen saturation decreased
Nasopharyngitis (inflammation of the nasopharynx)
Back pain
Blood pressure increased
Pain in extremity
Blood pressure fluctuation
Decreased appetite
Diabetes mellitus inadequate control
Drug ineffective

What are the existing conditions these people have? *

Insomnia (sleeplessness): 6 people, 20.69%
Depression: 6 people, 20.69%
Osteoporosis (bones weak and more likely to break): 5 people, 17.24%
Lupus-Like Syndrome (a disease symptom matches with lupus an immune disease): 5 people, 17.24%
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 5 people, 17.24%
Joint Pain: 4 people, 13.79%
Autoimmune Thrombocytopenia (isolated low platelet count (thrombocytopenia) with normal bone marrow and the absence of other causes of thrombocytopenia): 4 people, 13.79%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 10.34%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 10.34%
Pain: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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