Robaxin and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Robaxin (methocarbamol) and Linzess (linaclotide). Common drug interactions include nasopharyngitis among females and arthritis among males.

The phase IV clinical study analyzes what interactions people have when they take Robaxin and Linzess. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Robaxin?

Robaxin has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 9,109 Robaxin users. Check the latest studies of Robaxin.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

On Jul, 14, 2026

92 people who take Robaxin and Linzess together, and have interactions are studied.

What are the common drug interactions of Robaxin and Linzess, by gender? *:

female:

Nasopharyngitis (inflammation of the nasopharynx)
Nephrogenic anaemia (anaemia due to kidney disease)
Oesophageal stenosis (narrowing of oesophagus)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Periodic limb movement disorder
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Fall
Depression
Headache (pain in head)

male:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Bladder disorder
Blood gases
Cardiac failure congestive
Fall
Infection
Intervertebral disc protrusion (spinal disc protrusion)
Muscular weakness (muscle weakness)
Opiates positive
Rectal prolapse (falling of rectum from normal place)

What are the common drug interactions of Robaxin and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal pain
Costochondritis (chest wall pain)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Nausea (feeling of having an urge to vomit)
Pleurisy (inflammation of the pleurae, which causes pain when breathing)
Tardive dyskinesia (a disorder that involves involuntary movements)

40-49:

Alopecia (absence of hair from areas of the body)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Kyphosis (a condition of over-curvature of the thoracic vertebrae (upper back))
Lordosis (outward curve of the back bone)
Menopause (end of monthly cycles in women)
Oesophageal stenosis (narrowing of oesophagus)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Rash

50-59:

Ill-defined disorder
Intervertebral disc degeneration (spinal disc degeneration)
Knee arthroplasty
Migraine (headache)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Muscular weakness (muscle weakness)
Neck pain
Neuralgia (pain in one or more nerves)
Night sweats (sweating in night)

60+:

Fall
Diarrhoea
Fatigue (feeling of tiredness)
Infection
Insomnia (sleeplessness)
Muscular weakness (muscle weakness)
Pain
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Staphylococcal infection (an infection with staphylococcus bacteria)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 30 people, 32.61%
Pain: 14 people, 15.22%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 11.96%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 10.87%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 9 people, 9.78%
High Blood Pressure: 7 people, 7.61%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 7 people, 7.61%
Depression: 7 people, 7.61%
Drowsiness: 7 people, 7.61%
Stress And Anxiety: 6 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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