Robaxin and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Robaxin (methocarbamol) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include tooth fracture among females and abscess limb among males.

The phase IV clinical study analyzes what interactions people have when they take Robaxin and Zosyn. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Robaxin?

Robaxin has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 9,109 Robaxin users. Check the latest studies of Robaxin.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Aug, 11, 2026

13 people who take Robaxin and Zosyn together, and have interactions are studied.

What are the common drug interactions of Robaxin and Zosyn, by gender? *:

female:

Tooth fracture
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug hypersensitivity
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Dehydration (dryness resulting from the removal of water)

male:

Abscess limb (limb infection)
Groin abscess (pus in groin)
Blood calcium decreased
Blood creatinine increased
Blood urea increased
Cardiogenic shock (inadequate circulation of blood)
Genital abscess (build up of pus in genital)
Haematocrit decreased
Localised intraabdominal fluid collection (collection of fluid in abdomen in single site)
Septic shock (shock due to blood infection)

What are the common drug interactions of Robaxin and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Localised intraabdominal fluid collection (collection of fluid in abdomen in single site)
Septic shock (shock due to blood infection)
Urticaria (rash of round, red welts on the skin that itch intensely)
White blood cell count increased
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Aspartate aminotransferase increased
Blood calcium decreased
Blood creatinine increased
Blood urea increased

30-39:

Abscess limb (limb infection)
Anal abscess
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Scrotal abscess (pus in scrotum)
Sepsis (a severe blood infection that can lead to organ failure and death)

40-49:

Abdominal distension
Abdominal pain
Abdominal pain upper
Abscess limb (limb infection)
Anxiety
Balance disorder
Breast abscess
Breast cellulitis (spreading, acute inflammation of beast skin)
Chest pain
Chronic kidney disease

50-59:

Dehydration (dryness resulting from the removal of water)
Intestinal perforation (complete penetration of the wall of the intestine)
Acute respiratory failure
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Failure to thrive (inadequate weight gain and physical growth in children)
Haemorrhage intracranial (bleeding within the skull)
Hypotension (abnormally low blood pressure)
Pneumonia streptococcal (pneumonia, caused by streptococcus pneumoniae)
Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

Drug hypersensitivity

What are the existing conditions these people have? *

Weight Decreased: 2 people, 15.38%
Blood Pressure Abnormal: 2 people, 15.38%
Nausea (feeling of having an urge to vomit): 2 people, 15.38%
Pain: 2 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 15.38%
Type 2 Diabetes: 2 people, 15.38%
Bone Pain: 1 person, 7.69%
Breast Cancer Metastatic: 1 person, 7.69%
Cardiac Disorder: 1 person, 7.69%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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