Robitussin and Nuvigil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Robitussin (guaifenesin) and Nuvigil (armodafinil). Common drug interactions include decreased appetite among females and electrolyte imbalance among males.

The phase IV clinical study analyzes what interactions people have when they take Robitussin and Nuvigil. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Robitussin?

Robitussin has active ingredients of guaifenesin. eHealthMe is studying from 3,532 Robitussin users. Check the latest studies of Robitussin.

What is Nuvigil?

Nuvigil has active ingredients of armodafinil. It is often used in narcolepsy. eHealthMe is studying from 23,669 Nuvigil users. Check the latest studies of Nuvigil.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

30 people who take Robitussin and Nuvigil together, and have interactions are studied.

Robitussin and Nuvigil drug interactions.

What are the common drug interactions of Robitussin and Nuvigil, by gender? *:

female:

Decreased appetite
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

male:

Electrolyte imbalance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Poor quality sleep
Retinal vein occlusion (a blockage of the small veins that carry blood away from the retina)
Sensory disturbance (sense disturbance)
Thyroid disorder (thyroid diseases)
Visual acuity reduced (reduced clearness of vision)
Weight increased
Muscle spasms (muscle contraction)
Peripheral swelling

What are the common drug interactions of Robitussin and Nuvigil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Decreased appetite
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastritis (inflammation of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

40-49:

Fall
Anaemia (lack of blood)
Benign bone neoplasm (benign (non-cancerous) tumours of the bone)
Blood pressure decreased
Bronchitis bacterial (inflammation of the mucous membrane in the bronchial tubes due to bacterial infection)
Cardiac disorder
Cataplexy (loss of muscle tone accompanied by full conscious awareness)
Disturbance in attention
Dizziness
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)

50-59:

Electrolyte imbalance
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Muscle spasms (muscle contraction)
Peripheral swelling
Renal impairment (severely reduced kidney function)
Foot deformity (functional disability of foot)
Foot fracture

60+:

Fluid retention (an abnormal accumulation of fluid in the blood)
Pneumonia
Surgery

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 56.67%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 5 people, 16.67%
Drowsiness: 3 people, 10.00%
Nasal Septum Deviation (deviated nasal septum): 2 people, 6.67%
Hypersensitivity: 2 people, 6.67%
Acne (skin problems that cause pimples): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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