Robitussin and Promethazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Robitussin (guaifenesin) and Promethazine (promethazine hydrochloride). Common drug interactions include dna antibody positive among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Robitussin and Promethazine. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Robitussin?

Robitussin has active ingredients of guaifenesin. eHealthMe is studying from 3,532 Robitussin users. Check the latest studies of Robitussin.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

65 people who take Robitussin and Promethazine together, and have interactions are studied.

Robitussin and Promethazine drug interactions.

What are the common drug interactions of Robitussin and Promethazine, by gender? *:

female:

Dna antibody positive
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Enuresis (repeated inability to control urination)
Epistaxis (bleed from the nose)
Eye haemorrhage (bleeding in the eye)
Femoral neck fracture (neck of femur bone fracture)
Foot deformity (functional disability of foot)
Full blood count decreased
Gait disturbance

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Renal impairment (severely reduced kidney function)
Urinary tract infection
Abdominal pain
B-cell lymphoma (blood cancer affecting b cells)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)

What are the common drug interactions of Robitussin and Promethazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Actinic keratosis (skin disease due to sun exposure)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Arthralgia (joint pain)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Atelectasis (partial or complete collapse of the lung)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bronchitis viral (inflammation of the mucous membrane in the bronchial tubes due to infection with streptococcus pneumoniae)

20-29:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenia (weakness)
Chronic kidney disease
Emotional distress
Fatigue (feeling of tiredness)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Renal impairment (severely reduced kidney function)

30-39:

Anxiety
Chronic kidney disease
Depression
Emotional distress
Nephrogenic anaemia (anaemia due to kidney disease)
Osteoporosis (bones weak and more likely to break)
Pain
Renal failure (kidney dysfunction)
Skeletal injury (bone and supporting muscle injury)
Anosmia (partial or complete loss of the sense of smell)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Fall
Delivery
Maternal exposure during pregnancy (use of substance during pregnancy)
Agitation (state of anxiety or nervous excitement)
Anaemia (lack of blood)
Benign bone neoplasm (benign (non-cancerous) tumours of the bone)
Blood pressure decreased

50-59:

Stomatitis (inflammation of mucous membrane of mouth)
Migraine (headache)
Swelling
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Cough
Asthma
Chronic kidney disease
Diarrhoea
Drug ineffective
Fall

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Coagulopathy (blood's ability to clot is impaired)
Confusional state
Death
Decreased appetite
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 29.23%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 15 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 21.54%
Pain: 11 people, 16.92%
High Blood Pressure: 11 people, 16.92%
Nasopharyngitis (inflammation of the nasopharynx): 8 people, 12.31%
Cough: 8 people, 12.31%
Asthma: 8 people, 12.31%
Hiv Infection: 6 people, 9.23%
High Blood Cholesterol: 6 people, 9.23%

* Approximation only. Some reports may have incomplete information.

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