Robitussin and Rocephin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Robitussin (guaifenesin) and Rocephin (ceftriaxone sodium). Common drug interactions include anxiety among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Robitussin and Rocephin. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Robitussin?

Robitussin has active ingredients of guaifenesin. eHealthMe is studying from 3,532 Robitussin users. Check the latest studies of Robitussin.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

48 people who take Robitussin and Rocephin together, and have interactions are studied.

Robitussin and Rocephin drug interactions.

What are the common drug interactions of Robitussin and Rocephin, by gender? *:

female:

Anxiety
Asthenia (weakness)
Bipolar disorder (mood disorder)
Blood in stool
Blood pressure decreased
Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardioactive drug level above therapeutic
Compulsive shopping
Depression

male:

Pyrexia (fever)
Chronic kidney disease
Headache (pain in head)
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Night sweats (sweating in night)
Productive cough
Pruritus (severe itching of the skin)
Pseudomonas test positive
Secretion discharge

What are the common drug interactions of Robitussin and Rocephin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
Night sweats (sweating in night)
Productive cough
Pruritus (severe itching of the skin)
Pseudomonas test positive
Pyrexia (fever)
Secretion discharge
Sputum discoloured
Sputum increased
Staphylococcus test positive

40-49:

Anxiety
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Rigors (an episode of shaking or exaggerated shivering)

50-59:

Acute respiratory failure
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cellulitis (infection under the skin)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Corona virus infection (infection caused by a corona virus)
Cough
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)
Productive cough
Rhinovirus infection

60+:

Cardiac failure congestive
Contusion (a type of hematoma of tissue in which capillaries)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Malaise (a feeling of general discomfort or uneasiness)
Renal failure acute (rapid kidney dysfunction)
Blood pressure systolic increased
Carotid artery stenosis (narrowing of carotid artery)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cough
Dyspepsia (indigestion)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 14 people, 29.17%
Pain: 13 people, 27.08%
Stress And Anxiety: 10 people, 20.83%
Depression: 10 people, 20.83%
Wheezing (a high-pitched whistling sound made while you breath): 9 people, 18.75%
Constipation: 9 people, 18.75%
Cough: 8 people, 16.67%
Bacterial Infection: 7 people, 14.58%
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 7 people, 14.58%
Sleep Disorder: 7 people, 14.58%

* Approximation only. Some reports may have incomplete information.

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