Rocephin and Enbrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Enbrel (etanercept). Common drug interactions include stomatitis among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Enbrel. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

On Aug, 06, 2026

70 people who take Rocephin and Enbrel together, and have interactions are studied.

What are the common drug interactions of Rocephin and Enbrel, by gender? *:

female:

Stomatitis (inflammation of mucous membrane of mouth)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Thrombocytosis
Tooth abscess (pus formation in tooth)
Tooth disorder (tooth disease)
Tooth injury
Tricuspid valve incompetence (inefficient heart valve)
Tympanic membrane disorder (disease of ear drum)
Uterine leiomyoma (uterine benign tumour derived from smooth muscle)
Vasculitis (inflammation of a blood vessel or blood vessels)

male:

Drug ineffective
Renal failure acute (rapid kidney dysfunction)
Myalgia (muscle pain)
Neck pain
Pain
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Alpha haemolytic streptococcal infection (infections with alpha-haemolytic strep bacteria are common; many strains live naturally in humans)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Confusional state

What are the common drug interactions of Rocephin and Enbrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Chills (felling of cold)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Febrile convulsion (a convulsion associated with a significant rise in body temperature)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Influenza
Injection site bruising
Injection site haemorrhage (bleeding from injection site)
Injection site pain
Peripheral coldness
Pyrexia (fever)

10-19:

Back pain
Decreased appetite
Headache (pain in head)
Interstitial lung disease
Lacrimation increased
Mood swings (an extreme or rapid change in mood)
Ocular hyperaemia (an abnormally large amount of blood in eye)
Photophobia (extreme sensitivity to light)
Rhinorrhoea (watery mucus discharge from the nose)
Drug ineffective

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Blood cholesterol increased
Chest pain
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Activities of daily living impaired
Crying
Injection site erythema (redness at injection site)
Injection site pain

40-49:

Pain
Fall
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hip fracture
Mobility decreased (ability to move is reduced)
Respiratory tract congestion (blockage on respiratory system)
Alopecia (absence of hair from areas of the body)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Back pain

50-59:

Enterococcal infection
Escherichia infection (bacterial infection by escherichia coli)
Essential thrombocythaemia (chronic blood cancer)
Exostosis (formation of new bone on the surface of a bone)
Facial neuralgia (pain of face)
Foot fracture
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Generalised oedema (swelling all over the body)
Gingival infection (gum infection)
Gingival pain (gum pain)

60+:

Renal failure acute (rapid kidney dysfunction)
Arthralgia (joint pain)
Anxiety
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cytomegalovirus test positive
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 28 people, 40.00%
Osteoporosis (bones weak and more likely to break): 28 people, 40.00%
Thrombocytopenia (decrease of platelets in blood): 11 people, 15.71%
Pain: 5 people, 7.14%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 5.71%
Pneumonia: 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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