Rocephin and Hydrea drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Hydrea (hydroxyurea). Common drug interactions include influenza among females and coma among males.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Hydrea. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Hydrea?

Hydrea has active ingredients of hydroxyurea. It is often used in polycythemia vera. eHealthMe is studying from 9,083 Hydrea users. Check the latest studies of Hydrea.

On Jul, 14, 2026

35 people who take Rocephin and Hydrea together, and have interactions are studied.

What are the common drug interactions of Rocephin and Hydrea, by gender? *:

female:

Influenza
Infusion site haemorrhage (bleeding from infusion site)
International normalised ratio increased
Muscle spasms (muscle contraction)
Oedema peripheral (superficial swelling)
Pain
Pain in extremity
Pain in jaw
Pulmonary hypertension (increase in blood pressure in the lung artery)
Red blood cell count decreased

male:

Coma (state of unconsciousness lasting more than six hours)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Cardiac failure congestive
Haemoglobin decreased
Sinus arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle)
Thrombocytopenia (decrease of platelets in blood)
Headache (pain in head)
Activated partial thromboplastin time prolonged
Acute respiratory failure

What are the common drug interactions of Rocephin and Hydrea, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Back pain
Pyrexia (fever)

10-19:

Pyrexia (fever)
Cytolytic hepatitis (dissolution or destruction of a liver cell)
Hepatomegaly (abnormal enlargement of the liver)
Jaundice cholestatic
Pancreatitis (inflammation of pancreas)
Campylobacter infection (infection by the campylobacter bacterium)
Hepatic pain (pain in liver)
Abdominal pain
Hepatic enzyme increased
Liver disorder (liver diseases)

20-29:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Alanine aminotransferase increased
Aspartate aminotransferase increased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Acute respiratory failure
Brain abscess
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cerebral haemorrhage (bleeding within the brain)

30-39:

Coma (state of unconsciousness lasting more than six hours)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Hallucination, visual (seeing things that aren't there)
Dermatitis exfoliative (widespread scaling of the skin, often with itching (pruritus), skin redness (erythroderma), and hair loss)
Hallucination (an experience involving the perception of something not present)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pyrexia (fever)
Headache (pain in head)
Cellulitis (infection under the skin)

40-49:

Infusion site erythema (reddening of the skin at infusion site)
Infusion site pain
Insomnia (sleeplessness)
International normalised ratio decreased
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Oliguria (not enough urine)
Pallor
Pleural effusion (water on the lungs)

50-59:

Abdominal pain
Activated partial thromboplastin time prolonged
Arthralgia (joint pain)
Blood bilirubin increased
Blood lactate dehydrogenase increased
Cardiac failure congestive
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Fatigue (feeling of tiredness)
Haemoglobin decreased
Hepatic fibrosis (scarring process that represents the liver's response to injury)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Nausea (feeling of having an urge to vomit)
Pyelonephritis (inflammation of kidney caused by bacteria)
Pyrexia (fever)
Skin candida (fungal infection of skin)
Abdominal pain
Electrocardiogram qt prolonged
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Blood alkaline phosphatase increased

What are the existing conditions these people have? *

Fever: 15 people, 42.86%
Brain Abscess: 7 people, 20.00%
Campylobacter Infection (infection by the campylobacter bacterium): 7 people, 20.00%
Aspergillosis (an infection caused by a fungus called aspergillus): 6 people, 17.14%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 4 people, 11.43%
Pneumonia: 3 people, 8.57%
C-Reactive Protein Increased: 3 people, 8.57%
Cardiac Failure: 3 people, 8.57%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 3 people, 8.57%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 8.57%

* Approximation only. Some reports may have incomplete information.

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