Rocephin and Mepron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Mepron (atovaquone). Common drug interactions include poor dental condition among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Mepron. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Mepron?

Mepron has active ingredients of atovaquone. It is often used in babesiosis. eHealthMe is studying from 2,091 Mepron users. Check the latest studies of Mepron.

On Jul, 15, 2026

45 people who take Rocephin and Mepron together, and have interactions are studied.

What are the common drug interactions of Rocephin and Mepron, by gender? *:

female:

Poor dental condition
Pulpitis dental (inflammation of the tooth pulp)
Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Spinal osteoarthritis (joint cartilage loss in spine)
Stomatitis (inflammation of mucous membrane of mouth)
Swelling
Swelling face
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)

male:

Acute respiratory failure
Bone marrow failure
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Sepsis (a severe blood infection that can lead to organ failure and death)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Deformity (disfigurement)
Gallbladder disorder

What are the common drug interactions of Rocephin and Mepron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Activated partial thromboplastin time prolonged
Blood lactate dehydrogenase increased
Haematuria present (presence of blood in urine due to trauma)
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Haemolytic anaemia (anaemia due to haemolysis)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Renal failure acute (rapid kidney dysfunction)
Skin mass

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Gallbladder disorder
Injury
Pain
Deformity (disfigurement)
Pancreatitis (inflammation of pancreas)
Back pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

30-39:

Abdominal pain upper
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Eosinophil count increased
Feeling hot
Hepatitis (inflammation of the liver)
Neutropenia (an abnormally low number of neutrophils)
Pneumococcal infection (infection caused by streptococcus pneumoniae)
Pyrexia (fever)
Reticuloendothelial dysfunction
Vomiting

40-49:

Acute respiratory failure
Bone marrow failure
C-reactive protein increased
Cerebral toxoplasmosis (parasitic disease of brain caused by the protozoan toxoplasma gondii)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Eating disorder
Encephalitis (inflammation of the brain)
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Loss of consciousness
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

50-59:

Anxiety
Weight decreased
Cor pulmonale chronic (long lasting enlargement of the right ventricle of the heart)
Gastroduodenitis (an inflammation of the mucous membrane of the stomach and duodenum)
Nausea (feeling of having an urge to vomit)
Uterine enlargement
Cardiac failure congestive
Appendicitis (inflammation of the appendix)
Aptyalism (deficiency or absence of saliva)
Asthma

60+:

Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
Tremor (trembling or shaking movements in one or more parts of your body)
Troponin increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Chest pain

What are the existing conditions these people have? *

Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 28 people, 62.22%
Osteoporosis (bones weak and more likely to break): 28 people, 62.22%
Thrombocytopenia (decrease of platelets in blood): 11 people, 24.44%
Hiv Infection: 5 people, 11.11%
Encephalitis Cytomegalovirus (inflammation of the brain due to cytomegalovirus): 3 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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