Rocephin and Methotrexate sodium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Methotrexate sodium (methotrexate sodium). Common drug interactions include abdominal adhesions among females and febrile neutropenia among males.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Methotrexate sodium. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

On Jul, 11, 2026

22 people who take Rocephin and Methotrexate sodium together, and have interactions are studied.

Rocephin and Methotrexate sodium drug interactions.

What are the common drug interactions of Rocephin and Methotrexate Sodium, by gender? *:

female:

Abdominal adhesions (inflammation of abdomen)
Abdominal pain
Abdominal pain lower
Arthralgia (joint pain)
Asthenia (weakness)
Blood creatine phosphokinase increased
Blood lactate dehydrogenase increased
Body temperature increased
Chills (felling of cold)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

Febrile neutropenia (fever with reduced white blood cells)
Parainfluenzae virus infection
Bronchostenosis (narrowing of a bronchial tube by scarring or other stricture)
Fall
Hypokalaemia (low potassium)
Hypovolaemia (a decreased volume of circulating blood in the body)
Influenza like illness
Nasopharyngitis (inflammation of the nasopharynx)
Oral candidiasis (fungal infection of mouth)
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the common drug interactions of Rocephin and Methotrexate Sodium, by age (0-1 to 60+)? *:

0-1:

Bronchostenosis (narrowing of a bronchial tube by scarring or other stricture)
Hypokalaemia (low potassium)

2-9:

Disseminated intravascular coagulation (systemic activation of blood coagulation)
Pulmonary oedema (fluid accumulation in the lungs)
Respiratory distress (difficulty in breathing)

10-19:

Febrile neutropenia (fever with reduced white blood cells)
Parainfluenzae virus infection
Venoocclusive liver disease (small veins in the liver are obstructed)
Thrombocytopenia (decrease of platelets in blood)

20-29:

n/a

30-39:

n/a

40-49:

Abdominal adhesions (inflammation of abdomen)
Abdominal pain
Abdominal pain lower
Arthralgia (joint pain)
Asthenia (weakness)
Blood creatine phosphokinase increased
Blood lactate dehydrogenase increased
Body temperature increased
Chills (felling of cold)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

50-59:

Drug hypersensitivity

60+:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Renal failure acute (rapid kidney dysfunction)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Acute respiratory distress syndrome
Alanine aminotransferase increased
Aplasia (defective development or congenital absence of an organ or tissue)
Blood alkaline phosphatase increased

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 6 people, 27.27%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 13.64%
Peripheral T-Cell Lymphoma Unspecified (peripheral t-cell cancer unspecified): 3 people, 13.64%
Fever: 3 people, 13.64%
Encephalitis Viral (inflammation of the brain due to viral infection): 3 people, 13.64%
Bacterial Infection: 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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