Rocephin and Pentoxifylline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rocephin (ceftriaxone sodium) and Pentoxifylline (pentoxifylline). Common drug interactions include osteoporosis among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Rocephin and Pentoxifylline. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

What is Pentoxifylline?

Pentoxifylline has active ingredients of pentoxifylline. eHealthMe is studying from 5,997 Pentoxifylline users. Check the latest studies of Pentoxifylline.



On Jul, 03, 2026

11 people who take Rocephin and Pentoxifylline together, and have interactions are studied.

Rocephin and Pentoxifylline drug interactions.

What are the common drug interactions of Rocephin and Pentoxifylline, by gender? *:

female:

  1. Osteoporosis (bones weak and more likely to break)
  2. Peripheral vascular disorder
  3. Pleural disorder
  4. Pleural effusion (water on the lungs)
  5. Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
  6. Pulmonary mass
  7. Renal disorder (kidney disease)
  8. Renal failure acute (rapid kidney dysfunction)
  9. Renal failure chronic (long lasting kidney dysfunction)
  10. Respiration (transport of oxygen from the outside air to the cells within tissues)

male:

  1. Pyrexia (fever)
  2. Sepsis (a severe blood infection that can lead to organ failure and death)
  3. Fatigue (feeling of tiredness)
  4. General physical health deterioration (weak health status)
  5. Haptoglobin increased
  6. Hepatic enzyme increased
  7. Hepatomegaly (abnormal enlargement of the liver)
  8. Hypercalciuria (elevated calcium (ca+) level in the urine)
  9. Increased bronchial secretion
  10. Lethargy (tiredness)

What are the common drug interactions of Rocephin and Pentoxifylline, by age (0-1 to 60+)? *:

0-1:

  1. Pyrexia (fever)
  2. Sepsis (a severe blood infection that can lead to organ failure and death)
  3. Hypertension (high blood pressure)
  4. Vomiting
  5. Abdominal distension
  6. Anaemia (lack of blood)
  7. Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
  8. Cough
  9. Diarrhoea
  10. Faeces discoloured

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Abdominal wall haematoma (abdominal wall blood clotting)
  2. Acute respiratory failure
  3. Diastolic dysfunction
  4. Dizziness
  5. Drug hypersensitivity
  6. Dyspnoea (difficult or laboured respiration)
  7. Fatigue (feeling of tiredness)
  8. Haematoma (collection of blood outside the blood vessels)
  9. Hypokalaemia (low potassium)
  10. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)

What are the existing conditions these people have? *

  1. High Blood Pressure: 6 people, 54.55%
  2. Spinal Muscular Atrophy (wasting of spinal muscles): 5 people, 45.45%
  3. Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 36.36%
  4. Tumor Lysis Syndrome: 1 person, 9.09%
  5. Stress And Anxiety: 1 person, 9.09%
  6. Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 9.09%
  7. Pancreatic Carcinoma Stage Iv (pancreatic cancer stage iv): 1 person, 9.09%
  8. Nausea (feeling of having an urge to vomit): 1 person, 9.09%
  9. Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 1 person, 9.09%
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rocephin and Pentoxifylline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rocephin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Pentoxifylline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rocephin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Pentoxifylline and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ceftriaxone sodium and pentoxifylline (the active ingredients of Rocephin and Pentoxifylline, respectively), and Rocephin and Pentoxifylline (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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