Rogaine and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rogaine (minoxidil) and Melatonin (melatonin). Common drug interactions include overdose among females and basal cell carcinoma among males.

The phase IV clinical study analyzes what interactions people have when they take Rogaine and Melatonin. It is created by eHealthMe based on reports of 59 people who take the same drugs from the FDA, and is updated regularly.

What is Rogaine?

Rogaine has active ingredients of minoxidil. It is often used in hair loss. eHealthMe is studying from 34,083 Rogaine users. Check the latest studies of Rogaine.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 30, 2026

59 people who take Rogaine and Melatonin together, and have interactions are studied.

Rogaine and Melatonin drug interactions.

What are the common drug interactions of Rogaine and Melatonin, by gender? *:

female:

Overdose
Hair colour changes
Erythema (redness of the skin)
Pruritus (severe itching of the skin)
Hair disorder
Therapeutic response unexpected
Drug effect decreased
Pain of skin
Dizziness
Pain

male:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder cancer
Loss of consciousness
Malignant melanoma stage i (cancer has formed; the tumour is not more than 1 millimetre thick, with no ulceration)
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Malignant melanoma (skin cancer rises from melancytes)
Plasma cell myeloma (cancer that begins in plasma cells)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Ureteric cancer
Overdose

What are the common drug interactions of Rogaine and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Erythema (redness of the skin)
Lip dry
Lip exfoliation
Lymphadenopathy (disease or enlargement of lymph nodes)
Pruritus (severe itching of the skin)
Rash generalised (rash on most of body parts)
Scab (a hard coating on the skin formed during the wound healing)
Skin burning sensation
Skin irritation

40-49:

Fatigue (feeling of tiredness)
Fibromyalgia (a long-term condition which causes pain all over the body)
Visual impairment
Overdose
Abnormal dreams
Dizziness
Dry eye (lack of adequate tears)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Heart rate irregular
Hot flush (sudden feelings of heat)

50-59:

Hair colour changes
Overdose
Therapeutic response unexpected
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bladder cancer
Plasma cell myeloma (cancer that begins in plasma cells)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Ureteric cancer
Lymphoma (cancer that begins in immune system cells)
Drug ineffective

60+:

Overdose
Hair disorder
Hepatic enzyme decreased
Protein total increased
Seborrhoeic dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp)
Acne (skin problems that cause pimples)
Application site irritation
Application site pruritus (application site severe itching of the skin)
Burning sensation
Depression

What are the existing conditions these people have? *

Sleep Disorder: 29 people, 49.15%
High Blood Cholesterol: 11 people, 18.64%
High Blood Pressure: 9 people, 15.25%
Cardiac Disorder: 8 people, 13.56%
Stress And Anxiety: 8 people, 13.56%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 11.86%
Dry Eyes (lack of adequate tears): 6 people, 10.17%
Hair Growth Abnormal: 6 people, 10.17%
Multiple Allergies (allergy to multiple agents): 5 people, 8.47%
Depression: 5 people, 8.47%

* Approximation only. Some reports may have incomplete information.

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