Roxanol and Femara drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxanol (morphine sulfate) and Femara (letrozole). Common drug interactions include anxiety among females.

The phase IV clinical study analyzes what interactions people have when they take Roxanol and Femara. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Roxanol?

Roxanol has active ingredients of morphine sulfate. eHealthMe is studying from 807 Roxanol users. Check the latest studies of Roxanol.

What is Femara?

Femara has active ingredients of letrozole. It is often used in breast cancer. eHealthMe is studying from 19,630 Femara users. Check the latest studies of Femara.



On Jul, 28, 2026

15 people who take Roxanol and Femara together, and have interactions are studied.

Roxanol and Femara drug interactions.

What are the common drug interactions of Roxanol and Femara, by gender? *:

female:

  1. Anxiety
  2. Metastases to bone (cancer spreads to bone)
  3. Back pain
  4. Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
  5. Dizziness
  6. Fatigue (feeling of tiredness)
  7. Impaired healing
  8. Nausea (feeling of having an urge to vomit)
  9. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  10. Pain in jaw

male:

n/a

What are the common drug interactions of Roxanol and Femara, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
  2. Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
  3. Anaemia (lack of blood)
  4. Anaemia of malignant disease
  5. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  6. Anxiety
  7. Arteriosclerosis (thickening and hardening of arteries)
  8. Attention deficit/hyperactivity disorder
  9. Axillary mass
  10. Back pain

50-59:

  1. Anxiety
  2. Arthralgia (joint pain)
  3. Ascites (accumulation of fluid in the abdominal cavity)
  4. Asthenia (weakness)
  5. Atrophic vulvovaginitis (inflammation of the vulva)
  6. Back disorder
  7. Blindness
  8. Bone disorder
  9. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  10. Bruxism (habitual grinding of the teeth, typically during sleep)

60+:

  1. Anxiety
  2. Asthenia (weakness)
  3. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  4. Osteonecrosis of jaw (death of bone of jaw)
  5. Arthralgia (joint pain)
  6. Infection
  7. Malignant neoplasm progression (cancer tumour came back)
  8. Swelling
  9. Adrenal mass
  10. Anaemia (lack of blood)

What are the existing conditions these people have? *

  1. Pain: 10 people, 66.67%
  2. Nausea (feeling of having an urge to vomit): 6 people, 40.00%
  3. Constipation: 6 people, 40.00%
  4. Metastases To Bone (cancer spreads to bone): 4 people, 26.67%
  5. High Blood Pressure: 4 people, 26.67%
  6. Stress And Anxiety: 1 person, 6.67%
  7. Headache (pain in head): 1 person, 6.67%
  8. Fever: 1 person, 6.67%
  9. Breast Cancer Female: 1 person, 6.67%
  10. Back Pain: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Roxanol and Femara?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Roxanol and Femara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Roxanol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Femara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Roxanol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Femara and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate and letrozole (the active ingredients of Roxanol and Femara, respectively), and Roxanol and Femara (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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