Roxanol and Ondansetron drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxanol (morphine sulfate) and Ondansetron (ondansetron). Common drug interactions include hypokalaemia among females and hypotension among males.

The phase IV clinical study analyzes what interactions people have when they take Roxanol and Ondansetron. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Roxanol?

Roxanol has active ingredients of morphine sulfate. eHealthMe is studying from 807 Roxanol users. Check the latest studies of Roxanol.

What is Ondansetron?

Ondansetron has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 122,739 Ondansetron users. Check the latest studies of Ondansetron.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

22 people who take Roxanol and Ondansetron together, and have interactions are studied.

Roxanol and Ondansetron drug interactions.

What are the common drug interactions of Roxanol and Ondansetron, by gender? *:

female:

Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Leukocytosis (increased white blood cells)
Malaise (a feeling of general discomfort or uneasiness)
Malignant neoplasm progression (cancer tumour came back)
Memory impairment
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Metastases to central nervous system (cancer spreads to central nervous system)
Metastases to liver (cancer spreads to liver)
Oedema peripheral (superficial swelling)

male:

Hypotension (abnormally low blood pressure)
Radiation mucositis (inflammation of oral mucosa resulting from chemotherapeutic agents or ionizing radiation)
Dehydration (dryness resulting from the removal of water)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Disease progression
Dry skin
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Fungal skin infection

What are the common drug interactions of Roxanol and Ondansetron, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Completed suicide (act of taking one's own life)

30-39:

Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Fungal skin infection
Gait disturbance
Haemorrhagic diathesis (bleeding tendency)
Hypertension (high blood pressure)
Mucosal inflammation (infection of mucous membrane)
Pain
Pain in extremity

40-49:

n/a

50-59:

Radiation mucositis (inflammation of oral mucosa resulting from chemotherapeutic agents or ionizing radiation)
Febrile neutropenia (fever with reduced white blood cells)
Metastases to liver (cancer spreads to liver)
Neutropenia (an abnormally low number of neutrophils)
Oropharyngeal pain
Arrhythmia (irregular heartbeat)
Ascites (accumulation of fluid in the abdominal cavity)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood calcium decreased
Blood potassium decreased

60+:

Hypotension (abnormally low blood pressure)
Anaemia (lack of blood)
Dehydration (dryness resulting from the removal of water)
Depressed level of consciousness
Diastolic dysfunction
Dizziness
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)

What are the existing conditions these people have? *

Pain: 8 people, 36.36%
Stress And Anxiety: 6 people, 27.27%
Lung Cancer - Non-Small Cell (lung cancer): 6 people, 27.27%
Renal Cell Carcinoma (a kidney cancer): 4 people, 18.18%
Nausea And Vomiting: 4 people, 18.18%
Dyspnea (difficult or laboured breathing): 4 people, 18.18%
Secretion Discharge: 3 people, 13.64%
Fever: 3 people, 13.64%
Constipation: 3 people, 13.64%
Agitation (state of anxiety or nervous excitement): 3 people, 13.64%

* Approximation only. Some reports may have incomplete information.

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