Roxicet and Fentanyl-100 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxicet (acetaminophen; oxycodone hydrochloride) and Fentanyl-100 (fentanyl). Common drug interactions include tooth loss among females and narcotic intoxication among males.

The phase IV clinical study analyzes what interactions people have when they take Roxicet and Fentanyl-100. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

What is Fentanyl-100?

Fentanyl-100 has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 7,047 Fentanyl-100 users. Check the latest studies of Fentanyl-100.

On Aug, 12, 2026

21 people who take Roxicet and Fentanyl-100 together, and have interactions are studied.

Roxicet and Fentanyl-100 drug interactions.

What are the common drug interactions of Roxicet and Fentanyl-100, by gender? *:

female:

Tooth loss
Upper respiratory tract infection
Abdominal pain
Abscess jaw (tooth abscess or root abscess)
Biliary dilatation
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures)
Fall
Gallbladder enlargement
Hepatitis (inflammation of the liver)

male:

Narcotic intoxication (a condition caused by use of narcotic agents)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Application site bleeding
Application site erythema (redness of the skin at application site)
Application site pain
Blood phosphorus decreased
Blood sodium decreased
Brain natriuretic peptide increased
Bronchopneumonia (inflammation of the lungs, arising in the bronchi or bronchioles)
Confusional state

What are the common drug interactions of Roxicet and Fentanyl-100, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hemiparesis (weakness on one side of the body)
Locked-in syndrome (a condition in which a patient is aware and awake but cannot move or communicate verbally due to complete paralysis)
Respiratory distress (difficulty in breathing)
Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pulmonary congestion (congestion in the lungs)
Application site irritation
Bone pain
Diarrhoea
Drug ineffective
Eating disorder
Rectal haemorrhage (bleeding from anus)
Burning sensation
Chest pain

60+:

Application site bleeding
Application site erythema (redness of the skin at application site)
Hypotension (abnormally low blood pressure)
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Platelet count increased
Pyrexia (fever)
Red blood cell count decreased
Application site pain
Blood phosphorus decreased

What are the existing conditions these people have? *

Procedural Pain: 4 people, 19.05%
Oropharyngeal Pain: 4 people, 19.05%
Breakthrough Pain: 4 people, 19.05%
Back Pain: 4 people, 19.05%
Neuropathy Peripheral (surface nerve damage): 3 people, 14.29%
Chest Pain: 3 people, 14.29%
Stress And Anxiety: 2 people, 9.52%
Oral Cancer (mouth cancer): 2 people, 9.52%
Metastases To Bone (cancer spreads to bone): 2 people, 9.52%
Breast Cancer Metastatic: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

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