Roxicet and Proamatine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxicet (acetaminophen; oxycodone hydrochloride) and Proamatine (midodrine hydrochloride). Common drug interactions include cellulitis among females and polyarthritis among males.

The phase IV clinical study analyzes what interactions people have when they take Roxicet and Proamatine. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

What is Proamatine?

Proamatine has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 968 Proamatine users. Check the latest studies of Proamatine.

On Aug, 07, 2026

18 people who take Roxicet and Proamatine together, and have interactions are studied.

Roxicet and Proamatine drug interactions.

What are the common drug interactions of Roxicet and Proamatine, by gender? *:

female:

Cellulitis (infection under the skin)
Coagulopathy (blood's ability to clot is impaired)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deafness
Decreased appetite
Dilatation ventricular
Dysgeusia (disorder of the sense of taste)
Dysphagia (a condition in which swallowing is difficult or painful)
Ejection fraction decreased (systolic heart failure)
Enterococcus test positive

male:

Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Septic shock (shock due to blood infection)
Arrhythmia (irregular heartbeat)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Arteriovenous fistula site complication
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)

What are the common drug interactions of Roxicet and Proamatine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Deformity (disfigurement)
Device related infection
Erythema (redness of the skin)
Muscle tightness
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain in extremity
Polyarthritis (arthritis which involves 5 or more joints simultaneously)

40-49:

n/a

50-59:

Cellulitis (infection under the skin)
Coagulopathy (blood's ability to clot is impaired)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deafness
Decreased appetite
Dilatation ventricular
Dysgeusia (disorder of the sense of taste)
Dysphagia (a condition in which swallowing is difficult or painful)
Ejection fraction decreased (systolic heart failure)
Enterococcus test positive

60+:

Abscess neck (neck abscesses)
Addison's disease (addison's disease, a hormonal disorder disease)
Arthralgia (joint pain)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone disorder
Breast calcifications (deposits of calcium that can be seen on a mammogram of the breast)
Breast haematoma (blood-filled swelling in the breast)
Cardiac arrest
Cardiac disorder

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 17 people, 94.44%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 17 people, 94.44%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 12 people, 66.67%
Nuclear Magnetic Resonance Imaging Brain: 1 person, 5.56%
Nuclear Magnetic Resonance Imaging Abdominal: 1 person, 5.56%
Kidney Transplant Rejection: 1 person, 5.56%
High Blood Pressure: 1 person, 5.56%
High Blood Cholesterol: 1 person, 5.56%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.56%
Bleeding Disorders: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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