Roxicet and Sertraline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxicet (acetaminophen; oxycodone hydrochloride) and Sertraline (sertraline hydrochloride). Common drug interactions include lumbar vertebral fracture among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Roxicet and Sertraline. It is created by eHealthMe based on reports of 52 people who take the same drugs from the FDA, and is updated regularly.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,304 Sertraline users. Check the latest studies of Sertraline.

On Jul, 10, 2026

52 people who take Roxicet and Sertraline together, and have interactions are studied.

Roxicet and Sertraline drug interactions.

What are the common drug interactions of Roxicet and Sertraline, by gender? *:

female:

Lumbar vertebral fracture
Myalgia (muscle pain)
Neurofibroma (non-cancerous tumours that grow on nerves throughout the body)
Neuropathy peripheral (surface nerve damage)
Osteomyelitis (infection of bone)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Plasmacytoma (neoplasm of plasma cells (usually in bone marrow))
Pneumonia
Radicular pain (pain ""radiated"" along the dermatome (sensory distribution) of a nerve due to inflammation)

male:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Atelectasis (partial or complete collapse of the lung)
Back pain
Bacterial infection
Blood immunoglobulin a increased
Blood immunoglobulin g increased
Bone disorder

What are the common drug interactions of Roxicet and Sertraline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nausea (feeling of having an urge to vomit)
Drug dependence
Emotional disorder
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypertension (high blood pressure)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Insomnia (sleeplessness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Restless legs syndrome (a powerful urge to move your legs)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Chest pain
Death
Drug dependence
Gastroenteritis (inflammation of stomach and intestine)

40-49:

Abdominal pain upper
Actinomycosis (infection that causes sores, or abscesses)
Anaemia (lack of blood)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Atelectasis (partial or complete collapse of the lung)
Back pain
Blood immunoglobulin a increased
Blood immunoglobulin g increased
Bone disorder
Bone marrow disorder

50-59:

Dehydration (dryness resulting from the removal of water)
Dizziness
Electrolyte imbalance
Hepatic cyst
Hepatic steatosis (fatty liver disease)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hydronephrosis (water inside the kidney)
Immunosuppression
Intestinal obstruction
Iron deficiency anaemia

60+:

Anaemia (lack of blood)
Arthralgia (joint pain)
Groin pain
Injury
Intervertebral disc disorder (spinal disc disorder)
Joint effusion (presence of extra fluid in joint covering)
Leukopenia (less number of white blood cells in blood)
Lumbar vertebral fracture
Multiple myeloma (cancer of the plasma cells)
Myalgia (muscle pain)

What are the existing conditions these people have? *

Muscle Spasms (muscle contraction): 12 people, 23.08%
High Blood Pressure: 12 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 23.08%
Infection: 6 people, 11.54%
Hyperlipidaemia (presence of excess lipids in the blood): 6 people, 11.54%
High Blood Cholesterol: 6 people, 11.54%
Stress And Anxiety: 5 people, 9.62%
Diabetes: 5 people, 9.62%
Neuralgia (pain in one or more nerves): 4 people, 7.69%
Indigestion: 3 people, 5.77%

* Approximation only. Some reports may have incomplete information.

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