Roxicodone and Bumex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Roxicodone (oxycodone hydrochloride) and Bumex (bumetanide). Common drug interactions include gastrooesophageal reflux disease among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Roxicodone and Bumex. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Roxicodone?

Roxicodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 20,099 Roxicodone users. Check the latest studies of Roxicodone.

What is Bumex?

Bumex has active ingredients of bumetanide. It is often used in swelling. eHealthMe is studying from 9,210 Bumex users. Check the latest studies of Bumex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 04, 2026

65 people who take Roxicodone and Bumex together, and have interactions are studied.

What are the common drug interactions of Roxicodone and Bumex, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Haemoglobin decreased
Headache (pain in head)
Respiratory distress (difficulty in breathing)
Sepsis (a severe blood infection that can lead to organ failure and death)
Vomiting
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Acute respiratory failure
Anaemia of chronic disease

male:

Pneumonia
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Sepsis (a severe blood infection that can lead to organ failure and death)
Hypoxia (low oxygen in tissues)
Neutropenia (an abnormally low number of neutrophils)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure
Death
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)

What are the common drug interactions of Roxicodone and Bumex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematuria (presence of blood in urine)

20-29:

Hepatobiliary disease (diseases affect the liver and/or biliary tract)

30-39:

Abdominal pain
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Ascites (accumulation of fluid in the abdominal cavity)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoglobin decreased
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hand fracture
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)

40-49:

Cardiac failure acute
Cardiac failure congestive
Chest pain
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Hypoxia (low oxygen in tissues)
Interstitial lung disease

50-59:

Impaired gastric emptying
Interstitial lung disease
Iron deficiency anaemia
Leukocytosis (increased white blood cells)
Microcytic anaemia (a generic term for any type of anaemia characterized by small red blood cells)
Oesophageal dilatation (enlarged oesophagus)
Oesophageal obstruction (blockage of oesophagus)
Orthopnoea (shortness of breath (dyspnea) when lying down)
Oxygen saturation decreased
Platelet count increased

60+:

Oedema peripheral (superficial swelling)
Pneumonia
Diaphragmatic disorder
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Nervousness
Overlap syndrome (an autoimmune disease of connective tissue)
Pickwickian syndrome (extreme obesity accompanied by sleepiness, hypoventilation, and polycythemia)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 14 people, 21.54%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 8 people, 12.31%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.77%
Nausea And Vomiting: 6 people, 9.23%
Insomnia (sleeplessness): 6 people, 9.23%
Constipation: 6 people, 9.23%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 7.69%
Pulmonary Congestion (congestion in the lungs): 4 people, 6.15%
Pneumonia: 4 people, 6.15%
Indigestion: 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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