Rozerem and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rozerem (ramelteon) and Actos (pioglitazone hydrochloride). Common drug interactions include pancreatitis chronic among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Rozerem and Actos. It is created by eHealthMe based on reports of 45 people who take the same drugs from the FDA, and is updated regularly.

What is Rozerem?

Rozerem has active ingredients of ramelteon. It is often used in insomnia. eHealthMe is studying from 7,539 Rozerem users. Check the latest studies of Rozerem.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 17, 2026

45 people who take Rozerem and Actos together, and have interactions are studied.

What are the common drug interactions of Rozerem and Actos, by gender? *:

female:

Pancreatitis chronic (chronic inflammation of pancreas)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Renal impairment (severely reduced kidney function)
Skin lesion
Tooth loss
Toothache (tooth pain)
Urinary tract infection
Weight increased
Anaemia (lack of blood)
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Cellulitis (infection under the skin)
Acute myocardial infarction (acute heart attack)
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Constipation
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Epistaxis (bleed from the nose)
Eyelid oedema (eyelids are swollen and contain excessive fluid)

What are the common drug interactions of Rozerem and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Pancreatitis chronic (chronic inflammation of pancreas)
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Pancreatitis acute (sudden inflammation of pancreas)
Papillary thyroid cancer
Post procedural hypothyroidism

40-49:

Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Arrhythmia (irregular heartbeat)
Cardiac disorder
Cough
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Menopausal symptoms
Mitral valve incompetence (inefficient heart valve)
Neuropathy peripheral (surface nerve damage)

50-59:

Chronic kidney disease
Cellulitis (infection under the skin)
Osteonecrosis of jaw (death of bone of jaw)
Sepsis (a severe blood infection that can lead to organ failure and death)
Renal failure (kidney dysfunction)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Constipation

60+:

Diarrhoea
Pneumonia
Epistaxis (bleed from the nose)
Eyelid oedema (eyelids are swollen and contain excessive fluid)
Gastroenteritis (inflammation of stomach and intestine)
Hypersensitivity
Mouth haemorrhage (bleeding from mouth)
Multi-organ failure (multisystem organ failure)
Muscle haemorrhage (bleeding in muscle)
Overdose

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 20.00%
High Blood Pressure: 8 people, 17.78%
Pain: 7 people, 15.56%
Gastric Ulcer (stomach ulcer): 7 people, 15.56%
Neuralgia (pain in one or more nerves): 6 people, 13.33%
High Blood Cholesterol: 5 people, 11.11%
Depression: 5 people, 11.11%
Constipation: 4 people, 8.89%
Sleep Disorder: 4 people, 8.89%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 8.89%

* Approximation only. Some reports may have incomplete information.

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