Rozerem and Tecfidera drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rozerem (ramelteon) and Tecfidera (dimethyl fumarate). Common drug interactions include fatigue among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Rozerem and Tecfidera. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Rozerem?

Rozerem has active ingredients of ramelteon. It is often used in insomnia. eHealthMe is studying from 7,539 Rozerem users. Check the latest studies of Rozerem.

What is Tecfidera?

Tecfidera has active ingredients of dimethyl fumarate. It is often used in multiple sclerosis. eHealthMe is studying from 129,627 Tecfidera users. Check the latest studies of Tecfidera.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

27 people who take Rozerem and Tecfidera together, and have interactions are studied.

Rozerem and Tecfidera drug interactions.

What are the common drug interactions of Rozerem and Tecfidera, by gender? *:

female:

Fatigue (feeling of tiredness)
Vomiting
Actinic keratosis (skin disease due to sun exposure)
Asthenia (weakness)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bowen's disease (early stage of skin cancer)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Drug ineffective
Lymphocyte count decreased
Maternal exposure during pregnancy (use of substance during pregnancy)

male:

Fall
Flushing (the warm, red condition of human skin)
Depressed level of consciousness
Depression
Device failure
Diarrhoea
Fatigue (feeling of tiredness)
Foot fracture
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Pain

What are the common drug interactions of Rozerem and Tecfidera, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Maternal exposure during pregnancy (use of substance during pregnancy)
Visual field defect

30-39:

Fall
Dyslipidaemia (abnormal amount of lipids)
Spinal compression fracture (fracture due to spinal compression on bone)
Abnormal behaviour
Anxiety
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Depression
Device failure
Diarrhoea
Fatigue (feeling of tiredness)

40-49:

Knee arthroplasty
Thrombosis (formation of a blood clot inside a blood vessel)

50-59:

Fatigue (feeling of tiredness)
Actinic keratosis (skin disease due to sun exposure)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bowen's disease (early stage of skin cancer)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Balance disorder
Burning sensation
Decreased interest
Depression
Gait disturbance

60+:

Bradycardia (abnormally slow heart action)
Coma (state of unconsciousness lasting more than six hours)
Pyelonephritis acute (sudden inflammation of kidney caused by bacteria)
Urinary retention (the inability to completely or partially empty the bladder)
Drug ineffective
Gallbladder disorder
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Decreased appetite
Depressed level of consciousness
Pneumonia

What are the existing conditions these people have? *

Dizziness: 3 people, 11.11%
Depression: 3 people, 11.11%
Constipation: 3 people, 11.11%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 7.41%
Neurosis (a class of functional mental disorders involving distress but neither delusions nor hallucinations): 2 people, 7.41%
Neuropathy Peripheral (surface nerve damage): 2 people, 7.41%
Neuralgia (pain in one or more nerves): 2 people, 7.41%
High Blood Pressure: 2 people, 7.41%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 7.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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