Rybelsus and Bumetanide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rybelsus (semaglutide) and Bumetanide (bumetanide). Common drug interactions include nausea among females and amnesia among males.

The phase IV clinical study analyzes what interactions people have when they take Rybelsus and Bumetanide. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Bumetanide?

Bumetanide has active ingredients of bumetanide. It is often used in fluid retention. eHealthMe is studying from 20,532 Bumetanide users. Check the latest studies of Bumetanide.

On Jul, 14, 2026

14 people who take Rybelsus and Bumetanide together, and have interactions are studied.

Rybelsus and Bumetanide drug interactions.

What are the common drug interactions of Rybelsus and Bumetanide, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Vomiting
Arthralgia (joint pain)
Pain
Allergy to chemicals
Dehydration (dryness resulting from the removal of water)
Dizziness
Flushing (the warm, red condition of human skin)
Hypokalaemia (low potassium)

male:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Ejection fraction (the percentage of blood that is pumped out of a filled ventricle as a result of a heartbeat)
Renal impairment (severely reduced kidney function)
Weight increased
Blood pressure decreased
Cardiac output decreased
Dyspnoea (difficult or laboured respiration)
Peripheral swelling
Renal disorder (kidney disease)

What are the common drug interactions of Rybelsus and Bumetanide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Headache (pain in head)
Allergy to chemicals
Anaphylactic reaction (serious allergic reaction)
Dehydration (dryness resulting from the removal of water)
Dizziness
Flushing (the warm, red condition of human skin)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)

50-59:

Abdominal discomfort
Anxiety
Labile hypertension (wildly fluctuating blood pressure)
Nausea (feeling of having an urge to vomit)
Obesity (having too much body fat)
Pain
Panic attack
Peripheral swelling
Respiratory depression (respiration has a rate below 12 breaths)
Vomiting

60+:

n/a

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 28.57%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 21.43%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 2 people, 14.29%
Pericarditis Lupus (inflammation of the pericardium with red ulcerations on the face): 2 people, 14.29%
Nausea And Vomiting: 2 people, 14.29%
Immunodeficiency Common Variable: 2 people, 14.29%
Breast Cancer: 2 people, 14.29%
Pain: 1 person, 7.14%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 7.14%
Drowsiness: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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