Rybelsus and Farxiga drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rybelsus (semaglutide) and Farxiga (dapagliflozin). Common drug interactions include pain among females and blood glucose increased among males.

The phase IV clinical study analyzes what interactions people have when they take Rybelsus and Farxiga. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Farxiga?

Farxiga has active ingredients of dapagliflozin. It is often used in diabetes. eHealthMe is studying from 18,798 Farxiga users. Check the latest studies of Farxiga.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

62 people who take Rybelsus and Farxiga together, and have interactions are studied.

What are the common drug interactions of Rybelsus and Farxiga, by gender? *:

female:

Pain
Pain in jaw
Pancreatitis (inflammation of pancreas)
Pneumonia
Pruritus (severe itching of the skin)
Respiratory syncytial virus infection (viral disease of respiratory system)
Toothache (tooth pain)
Vertigo
Chills (felling of cold)
Constipation

male:

Blood glucose increased
Asthenia (weakness)
Back pain
Blood disorder
Cardiac output decreased
Contusion (a type of hematoma of tissue in which capillaries)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Fatigue (feeling of tiredness)

What are the common drug interactions of Rybelsus and Farxiga, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood glucose increased
Chest pain
Glomerular filtration rate decreased
Malaise (a feeling of general discomfort or uneasiness)
Pulseless electrical activity

40-49:

Dizziness
Lymph node pain
Lymphadenopathy (disease or enlargement of lymph nodes)
Nausea (feeling of having an urge to vomit)
Asthenia (weakness)
Diarrhoea

50-59:

Malaise (a feeling of general discomfort or uneasiness)
Pneumonia
Dizziness
Vomiting
Bone pain
Fall
Fractured coccyx (fracture tail bone)
Headache (pain in head)
Infection
Ocular hyperaemia (an abnormally large amount of blood in eye)

60+:

Back pain
Fatigue (feeling of tiredness)
Urine abnormality
Urine output increased
Pancreatic carcinoma stage iv (pancreatic cancer stage iv)
Abdominal pain upper
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood calcium increased
Blood disorder
Blood glucose decreased

What are the existing conditions these people have? *

Type 2 Diabetes: 10 people, 16.13%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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