Rybelsus and Tramadol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rybelsus (semaglutide) and Tramadol (tramadol hydrochloride). Common drug interactions include localised infection among females and surgery among males.

The phase IV clinical study analyzes what interactions people have when they take Rybelsus and Tramadol. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Rybelsus?

Rybelsus has active ingredients of semaglutide. eHealthMe is studying from 4,159 Rybelsus users. Check the latest studies of Rybelsus.

What is Tramadol?

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 235,798 Tramadol users. Check the latest studies of Tramadol.

On Jul, 16, 2026

33 people who take Rybelsus and Tramadol together, and have interactions are studied.

Rybelsus and Tramadol drug interactions.

What are the common drug interactions of Rybelsus and Tramadol, by gender? *:

female:

Localised infection (infection at the single location)
Loss of consciousness
Muscular weakness (muscle weakness)
Pharyngitis streptococcal (inflammation of the pharynx caused by infection from. streptococcus)
Procedural pain
Red blood cell sedimentation rate increased
Nausea (feeling of having an urge to vomit)
Vomiting
Depression
Diarrhoea

male:

Surgery
Abdominal pain upper
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Electrocardiogram st segment elevation
Febrile neutropenia (fever with reduced white blood cells)
Flatulence (flatus expelled through the anus)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Generalised oedema (swelling all over the body)
Gram stain positive
Hepatic steatosis (fatty liver disease)

What are the common drug interactions of Rybelsus and Tramadol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Headache (pain in head)
Anaphylactic reaction (serious allergic reaction)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Kidney infection
Nausea (feeling of having an urge to vomit)
Procedural pain
Urinary tract infection

50-59:

Anxiety
Nausea (feeling of having an urge to vomit)
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Surgery
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Abdominal discomfort
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Depressed level of consciousness

60+:

Nausea (feeling of having an urge to vomit)
Vomiting
Fatigue (feeling of tiredness)
Haematochezia (passage of stools containing blood)
Haemoglobin decreased
Haemorrhoidal haemorrhage (bleeding from the haemorrhoids)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyperhidrosis (abnormally increased sweating)
Hypokalaemia (low potassium)
International normalised ratio increased

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 12.12%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 12.12%
Type 2 Diabetes: 3 people, 9.09%
Multiple Myeloma (cancer of the plasma cells): 3 people, 9.09%
Diabetes: 3 people, 9.09%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.06%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 6.06%
Drowsiness: 2 people, 6.06%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 6.06%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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