Rydapt and Tylenol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rydapt (midostaurin) and Tylenol (acetaminophen). Common drug interactions include hyperbilirubinaemia among females and acute megakaryocytic leukaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Rydapt and Tylenol. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Rydapt?

Rydapt has active ingredients of midostaurin. eHealthMe is studying from 2,005 Rydapt users. Check the latest studies of Rydapt.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,309 Tylenol users. Check the latest studies of Tylenol.

On Jul, 14, 2026

19 people who take Rydapt and Tylenol together, and have interactions are studied.

What are the common drug interactions of Rydapt and Tylenol, by gender? *:

female:

Hyperbilirubinaemia (excess of bilirubin in the blood)
Leukaemic retinopathy (presence of a yellow-orange fundus of eye due to blood cancer)
Thrombocytopenia (decrease of platelets in blood)
Abdominal discomfort
Antinuclear antibody positive
Colitis (inflammation of colon)
Diarrhoea
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Dyspnoea (difficult or laboured respiration)
Generalised oedema (swelling all over the body)

male:

Acute megakaryocytic leukaemia (bone marrow cancer)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
White blood cell count increased
Abdominal pain upper
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Fatigue (feeling of tiredness)
Gallbladder disorder
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Cholecystitis infective (infection of gallbladder capable to infect other organs)

What are the common drug interactions of Rydapt and Tylenol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Hyperbilirubinaemia (excess of bilirubin in the blood)
Abdominal discomfort
Antinuclear antibody positive
Colitis (inflammation of colon)
Diarrhoea
Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
Dyspnoea (difficult or laboured respiration)
Generalised oedema (swelling all over the body)
Oliguria (not enough urine)
Thrombocytopenia (decrease of platelets in blood)

50-59:

Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Dizziness
Fatigue (feeling of tiredness)
Hospitalisation
Nausea (feeling of having an urge to vomit)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)

60+:

Transaminases increased
White blood cell count increased
Abdominal pain upper
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Fatigue (feeling of tiredness)
Gallbladder disorder
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 13 people, 68.42%
High Blood Pressure: 9 people, 47.37%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 42.11%
Nausea (feeling of having an urge to vomit): 7 people, 36.84%
Constipation: 5 people, 26.32%
Lower Gastrointestinal Haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding): 4 people, 21.05%
Oropharyngeal Pain: 4 people, 21.05%
Leukocytosis (increased white blood cells): 4 people, 21.05%
Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 4 people, 21.05%
Diarrhea: 4 people, 21.05%

* Approximation only. Some reports may have incomplete information.

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