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Rytary and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rytary (carbidopa; levodopa) and Premarin (estrogens, conjugated). Common drug interactions include hallucination among females.

The phase IV clinical study analyzes what interactions people have when they take Rytary and Premarin. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Rytary?

Rytary has active ingredients of carbidopa; levodopa. eHealthMe is studying from 17,270 Rytary users. Check the latest studies of Rytary.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Aug, 11, 2026

48 people who take Rytary and Premarin together, and have interactions are studied.

Rytary and Premarin drug interactions.

What are the common drug interactions of Rytary and Premarin, by gender? *:

female:

  1. Hallucination (an experience involving the perception of something not present)
  2. Fall
  3. Hallucination, visual (seeing things that aren't there)
  4. Insomnia (sleeplessness)
  5. Mobility decreased (ability to move is reduced)
  6. Weight decreased
  7. Adverse event
  8. Cough
  9. Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
  10. Oropharyngeal discomfort (pain or irritation of oropharynx)

male:

n/a

What are the common drug interactions of Rytary and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Hallucination (an experience involving the perception of something not present)
  2. Tremor (trembling or shaking movements in one or more parts of your body)
  3. Abnormal behaviour
  4. Abnormal dreams
  5. Aggression
  6. Death
  7. Delusion (a false belief or opinion)
  8. Disturbance in attention
  9. Gait disturbance
  10. Memory impairment

What are the existing conditions these people have? *

  1. Parkinson's Disease: 42 people, 87.50%
  2. Hallucinations (sensations that appear real but are created by your mind): 11 people, 22.92%
  3. Sleep Disorder: 10 people, 20.83%
  4. Delusion (a false belief or opinion): 10 people, 20.83%
  5. Oestrogen Deficiency (lack of estrogens): 7 people, 14.58%
  6. Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness): 7 people, 14.58%
  7. Indigestion: 7 people, 14.58%
  8. Blood Pressure Abnormal: 7 people, 14.58%
  9. On And Off Phenomenon: 5 people, 10.42%
  10. High Blood Pressure: 5 people, 10.42%

* Approximation only. Some reports may have incomplete information.

Do you take Rytary and Premarin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Rytary and Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Rytary:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Premarin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Rytary and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Premarin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on carbidopa; levodopa and estrogens, conjugated (the active ingredients of Rytary and Premarin, respectively), and Rytary and Premarin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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