Rythmol and Tagamet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rythmol (propafenone hydrochloride) and Tagamet (cimetidine). Common drug interactions include transient ischaemic attack among females and burning sensation among males.

The phase IV clinical study analyzes what interactions people have when they take Rythmol and Tagamet. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Rythmol?

Rythmol has active ingredients of propafenone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 3,638 Rythmol users. Check the latest studies of Rythmol.

What is Tagamet?

Tagamet has active ingredients of cimetidine. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 9,011 Tagamet users. Check the latest studies of Tagamet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

15 people who take Rythmol and Tagamet together, and have interactions are studied.

What are the common drug interactions of Rythmol and Tagamet, by gender? *:

female:

Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Chest tightness
Drug hypersensitivity
Oxygen saturation decreased
Pyrexia (fever)
Anaemia (lack of blood)
Asthenia (weakness)
Normochromic normocytic anaemia (forms of anaemia in which the average size and haemoglobin content of the red blood cells are within normal limits)
Weight decreased

male:

Burning sensation
Deformity (disfigurement)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness
Swelling
Chronic kidney disease
Asthenia (weakness)
Decreased appetite
Diarrhoea
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Rythmol and Tagamet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Burning sensation
Deformity (disfigurement)
General physical health deterioration (weak health status)
Hypoaesthesia (reduced sense of touch or sensation)
Muscular weakness (muscle weakness)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Scar

60+:

Asthenia (weakness)
Chronic kidney disease
Renal failure (kidney dysfunction)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Weight decreased
Drug hypersensitivity
Pyrexia (fever)
Anaemia (lack of blood)
Decreased appetite
Diarrhoea

What are the existing conditions these people have? *

Pain: 7 people, 46.67%
Rashes (redness): 3 people, 20.00%
Nausea And Vomiting: 3 people, 20.00%
Headache (pain in head): 3 people, 20.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 13.33%
High Blood Cholesterol: 2 people, 13.33%
Calcium Metabolism Disorder (occur when the body has too little or too much calcium): 2 people, 13.33%
Cardiac Failure: 2 people, 13.33%
Dementia Alzheimer's Type (loss of mental ability with alzheimer's symptom): 2 people, 13.33%
Fungal Infection: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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