Sam-e and Cytomel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sam-e (same) and Cytomel (liothyronine sodium). Common drug interactions include abdominal discomfort among females.

The phase IV clinical study analyzes what interactions people have when they take Sam-e and Cytomel. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Sam-e?

Sam-e has active ingredients of same. It is often used in depression. eHealthMe is studying from 273 Sam-e users. Check the latest studies of Sam-e.

What is Cytomel?

Cytomel has active ingredients of liothyronine sodium. It is often used in hypothyroidism. eHealthMe is studying from 7,595 Cytomel users. Check the latest studies of Cytomel.



On Jul, 11, 2026

13 people who take Sam-e and Cytomel together, and have interactions are studied.

Sam-e and Cytomel drug interactions.

What are the common drug interactions of Sam-E and Cytomel, by gender? *:

female:

  1. Abdominal discomfort
  2. Upper respiratory tract infection
  3. Nasopharyngitis (inflammation of the nasopharynx)
  4. Pain
  5. Panic attack
  6. Seborrhoeic dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp)
  7. Acne (skin problems that cause pimples)
  8. Allergy to chemicals
  9. Anaphylactic reaction (serious allergic reaction)
  10. Anxiety

male:

n/a

What are the common drug interactions of Sam-E and Cytomel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Bone disorder
  2. Chondropathy (disease of the cartilage)
  3. Fatigue (feeling of tiredness)
  4. Immune system disorder
  5. Infection
  6. Injection site infection
  7. Muscle spasms (muscle contraction)
  8. Neck pain
  9. Pain
  10. Upper respiratory tract infection

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 76.92%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 76.92%
  3. Immunodeficiency Common Variable: 2 people, 15.38%
  4. Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Sam-e and Cytomel?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sam-e and Cytomel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sam-e:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cytomel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sam-e and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cytomel and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on same and liothyronine sodium (the active ingredients of Sam-e and Cytomel, respectively), and Sam-e and Cytomel (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: