Sam-e and Prilosec drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sam-e (same) and Prilosec (omeprazole). Common drug interactions include chronic kidney disease among females.

The phase IV clinical study analyzes what interactions people have when they take Sam-e and Prilosec. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Sam-e?

Sam-e has active ingredients of same. It is often used in depression. eHealthMe is studying from 273 Sam-e users. Check the latest studies of Sam-e.

What is Prilosec?

Prilosec has active ingredients of omeprazole. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 175,285 Prilosec users. Check the latest studies of Prilosec.



On Jul, 07, 2026

14 people who take Sam-e and Prilosec together, and have interactions are studied.

Sam-e and Prilosec drug interactions.

What are the common drug interactions of Sam-E and Prilosec, by gender? *:

female:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Drug ineffective
  4. Flushing (the warm, red condition of human skin)
  5. Hypersensitivity
  6. Infusion site haemorrhage (bleeding from infusion site)
  7. Injection site erythema (redness at injection site)
  8. Irritability
  9. Memory impairment
  10. Nausea (feeling of having an urge to vomit)

male:

n/a

What are the common drug interactions of Sam-E and Prilosec, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Chronic kidney disease
  2. Renal failure (kidney dysfunction)
  3. Nephrogenic anaemia (anaemia due to kidney disease)
  4. Drug ineffective
  5. Sedation

60+:

  1. Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
  2. Flushing (the warm, red condition of human skin)
  3. Nausea (feeling of having an urge to vomit)
  4. Vomiting

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 5 people, 35.71%
  2. Type 2 Diabetes: 3 people, 21.43%
  3. Stress And Anxiety: 3 people, 21.43%
  4. Bacterial Infection: 3 people, 21.43%
  5. Diabetes: 3 people, 21.43%
  6. Headache (pain in head): 3 people, 21.43%
  7. High Blood Cholesterol: 3 people, 21.43%
  8. High Blood Pressure: 3 people, 21.43%
  9. Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 21.43%
  10. Insomnia (sleeplessness): 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

Do you take Sam-e and Prilosec?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Sam-e and Prilosec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Sam-e:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Prilosec:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Sam-e and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prilosec and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on same and omeprazole (the active ingredients of Sam-e and Prilosec, respectively), and Sam-e and Prilosec (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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