Sam-e and Vitamin d drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sam-e (same) and Vitamin d (ergocalciferol). Common drug interactions include drug hypersensitivity among females and adverse event among males.

The phase IV clinical study analyzes what interactions people have when they take Sam-e and Vitamin d. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Sam-e?

Sam-e has active ingredients of same. It is often used in depression. eHealthMe is studying from 273 Sam-e users. Check the latest studies of Sam-e.

What is Vitamin d?

Vitamin d has active ingredients of ergocalciferol. It is often used in low vitamin d. eHealthMe is studying from 294,094 Vitamin d users. Check the latest studies of Vitamin d.

On Jul, 24, 2026

67 people who take Sam-e and Vitamin d together, and have interactions are studied.

What are the common drug interactions of Sam-E and Vitamin D, by gender? *:

female:

Drug hypersensitivity
Dyskinesia (abnormality or impairment of voluntary movement)
Dyspnoea (difficult or laboured respiration)
Erythema (redness of the skin)
Exostosis (formation of new bone on the surface of a bone)
Eye inflammation
Fluid retention (an abnormal accumulation of fluid in the blood)
Flushing (the warm, red condition of human skin)
Gastric ulcer haemorrhage (bleeding ulcer of stomach)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Adverse event
Food poisoning (poison in food)
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Hyperhidrosis (abnormally increased sweating)
Ill-defined disorder
Intracranial aneurysm (bulging, weak area in the wall of a cranial artery)
Malaise (a feeling of general discomfort or uneasiness)
Memory impairment
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the common drug interactions of Sam-E and Vitamin D, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fall
Rib fracture

40-49:

Heart rate increased
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Menstruation irregular
Premature menopause
Pyrexia (fever)
Somnolence (a state of near-sleep, a strong desire for sleep)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Thirst
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Fatigue (feeling of tiredness)
Chronic kidney disease
Renal failure (kidney dysfunction)
Arthralgia (joint pain)
Drug ineffective
Food poisoning (poison in food)
Nasopharyngitis (inflammation of the nasopharynx)
Nephrogenic anaemia (anaemia due to kidney disease)
Muscle spasms (muscle contraction)
Myalgia (muscle pain)

60+:

Palpitations (feelings or sensations that your heart is pounding or racing)
Headache (pain in head)
Gastrointestinal pain
Malaise (a feeling of general discomfort or uneasiness)
Nasopharyngitis (inflammation of the nasopharynx)
Tearfulness (excess tearing)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal discomfort
Adverse event
Anxiety

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 26 people, 38.81%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 25.37%
Immunodeficiency Common Variable: 7 people, 10.45%
Type 2 Diabetes: 4 people, 5.97%
High Blood Pressure: 4 people, 5.97%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 5.97%

* Approximation only. Some reports may have incomplete information.

Do you take Sam-e and Vitamin d?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously