Samsca and Solu-cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Samsca (tolvaptan) and Solu-cortef (hydrocortisone sodium succinate). Common drug interactions include haemolytic anaemia among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Samsca and Solu-cortef. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

On Jul, 16, 2026

19 people who take Samsca and Solu-cortef together, and have interactions are studied.

Samsca and Solu-cortef drug interactions.

What are the common drug interactions of Samsca and Solu-Cortef, by gender? *:

female:

Haemolytic anaemia (anaemia due to haemolysis)
Large intestine perforation (hole in large intestine)
Platelet count decreased
Abdominal pain
Arthralgia (joint pain)
Cardiac failure
Collagen disorder (infection and weakness of collagen)
Colon cancer
Drug eruption (adverse drug reaction of the skin)
Epistaxis (bleed from the nose)

male:

Cardiac failure
Hypotension (abnormally low blood pressure)
Bacterial infection
Blood pressure decreased
Chest pain
Cough
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)

What are the common drug interactions of Samsca and Solu-Cortef, by age (0-1 to 60+)? *:

0-1:

Cardiac failure
Hypotension (abnormally low blood pressure)
Pulmonary hypertension (increase in blood pressure in the lung artery)

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Asthma
Bacterial infection
Chest pain
Cough
Cystitis haemorrhagic (blood in the urine and painful voiding)
Cytomegalovirus viraemia (cytomegalo virus in blood stream)
Diarrhoea
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Graft versus host disease in lung (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the lung)
Hypertension (high blood pressure)

40-49:

Abdominal pain
Arthralgia (joint pain)
Cardiac failure
Hepatic enzyme increased
Platelet count decreased
Pulmonary hypertension (increase in blood pressure in the lung artery)

50-59:

Bacteraemia (presence of bacteria in the blood)
Cholangitis (infection of the bile duct)
Transplant rejection (a transplant material is not worked)
Klebsiella infection

60+:

Haemolytic anaemia (anaemia due to haemolysis)
Large intestine perforation (hole in large intestine)
Epistaxis (bleed from the nose)
Haemorrhage (bleeding)
Influenza
Infusion site erosion
Infusion site erythema (reddening of the skin at infusion site)
Infusion site induration
Infusion site pain
Infusion site swelling

What are the existing conditions these people have? *

Diabetes: 5 people, 26.32%
Insomnia (sleeplessness): 4 people, 21.05%
Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 4 people, 21.05%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 3 people, 15.79%
Hypotension (abnormally low blood pressure): 3 people, 15.79%
Nephrogenic Anaemia (anaemia due to kidney disease): 3 people, 15.79%
Cardiac Failure Congestive: 3 people, 15.79%
Anuria (failure of the kidneys to produce urine): 3 people, 15.79%
Oedema Due To Cardiac Disease (fluid collection in tissue due to heart disease): 3 people, 15.79%
Pleural Effusion (water on the lungs): 3 people, 15.79%

* Approximation only. Some reports may have incomplete information.

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