Sandimmune and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sandimmune (cyclosporine) and Fentanyl (fentanyl citrate). Common drug interactions include laryngeal oedema among females and graft versus host disease among males.

The phase IV clinical study analyzes what interactions people have when they take Sandimmune and Fentanyl. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Sandimmune?

Sandimmune has active ingredients of cyclosporine. eHealthMe is studying from 6,694 Sandimmune users. Check the latest studies of Sandimmune.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Jul, 18, 2026

35 people who take Sandimmune and Fentanyl together, and have interactions are studied.

Sandimmune and Fentanyl drug interactions.

What are the common drug interactions of Sandimmune and Fentanyl, by gender? *:

female:

Laryngeal oedema (swelling of larynx)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Myalgia (muscle pain)
Pneumonia
Rash erythematous (redness of the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Urinary tract infection
Abdominal adhesions (inflammation of abdomen)

male:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Respiratory failure (inadequate gas exchange by the respiratory system)
Coma (state of unconsciousness lasting more than six hours)
Fatigue (feeling of tiredness)
Hypersensitivity
Insomnia (sleeplessness)
Kidney transplant rejection
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Platelet count decreased
Renal failure (kidney dysfunction)

What are the common drug interactions of Sandimmune and Fentanyl, by age (0-1 to 60+)? *:

0-1:

Pyrexia (fever)
Infection
Acute hepatic failure
Alanine aminotransferase increased
Aspartate aminotransferase increased
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood glucose increased
Blood lactate dehydrogenase increased

2-9:

Somnolence (a state of near-sleep, a strong desire for sleep)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vasculitis (inflammation of a blood vessel or blood vessels)
Vision blurred
Visual acuity reduced (reduced clearness of vision)
Anaemia (lack of blood)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Haemorrhage (bleeding)
Mucosal erosion (peeling off of mucous membrane)
Mucosal inflammation (infection of mucous membrane)

10-19:

n/a

20-29:

Communication disorder (speech and language disorder)
Dyspnoea (difficult or laboured respiration)
Laryngeal oedema (swelling of larynx)
Rash erythematous (redness of the skin)
Agitation (state of anxiety or nervous excitement)
Anxiety
Coma (state of unconsciousness lasting more than six hours)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypoacusis (loss of hearing)
Inflammation

30-39:

Renal impairment (severely reduced kidney function)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)
Anaphylactic reaction (serious allergic reaction)
Death
Engraft failure
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Infection
Platelet count decreased
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

Central pontine myelinolysis (severe damage of nerve cells in brain)
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Muscle spasticity (tight or stiff muscles and an inability to control those muscles)
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Abdominal pain
Adhesion
Aphasia (damage to the parts of the brain that control language)
Chest discomfort
Dizziness
Drug ineffective

50-59:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Drug level increased
Hypersensitivity
Hypotension (abnormally low blood pressure)
Kidney transplant rejection
Respiratory disorder (respiratory disease)
Urine output decreased
Coma (state of unconsciousness lasting more than six hours)
Respiratory failure (inadequate gas exchange by the respiratory system)
Abdominal pain

60+:

Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Blood lactate dehydrogenase increased
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Gamma-glutamyltransferase increased
Insomnia (sleeplessness)
Diverticulum intestinal haemorrhagic (a pouch that is attached to the first part of the small intestine with bleeding)
General physical health deterioration (weak health status)
Melaena (the passage of black, tarry stools)
Hypoglycaemic coma (coma due to deficiency of glucose in the bloodstream)
Urinary tract infection

What are the existing conditions these people have? *

Sedation: 3 people, 8.57%
Interstitial Lung Disease: 3 people, 8.57%
Idiopathic Pulmonary Fibrosis (chronic lung disease): 3 people, 8.57%
Pneumocystis Jiroveci Pneumonia (fungal infection of the lungs): 2 people, 5.71%
Lung Infection: 2 people, 5.71%
Insomnia (sleeplessness): 2 people, 5.71%
Fungal Infection: 2 people, 5.71%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 2 people, 5.71%
Cytomegalovirus Infection: 2 people, 5.71%
Bacterial Infection: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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