Santyl and Cymbalta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Santyl (collagenase) and Cymbalta (duloxetine hydrochloride). Common drug interactions include weight decreased among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Santyl and Cymbalta. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Santyl?

Santyl has active ingredients of collagenase. eHealthMe is studying from 1,479 Santyl users. Check the latest studies of Santyl.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

On Jul, 19, 2026

32 people who take Santyl and Cymbalta together, and have interactions are studied.

What are the common drug interactions of Santyl and Cymbalta, by gender? *:

female:

Weight decreased
Chronic kidney disease
Poor peripheral circulation
Skin exfoliation (removal of the oldest dead skin cells)
Crying
Scab (a hard coating on the skin formed during the wound healing)
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Cardiac failure
Drug ineffective
Ischaemic limb pain (pain due to sudden lack of blood flow to a limb)

male:

Cellulitis (infection under the skin)
Acute respiratory failure
Application site irritation
Behcet's syndrome (involves inflammation of the blood vessels)
Blood pressure decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis (inflammation of colon)
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Intestinal polyp (small growths in the bowel with the potential for further growth)

What are the common drug interactions of Santyl and Cymbalta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Leukocytosis (increased white blood cells)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Cellulitis (infection under the skin)
Groin infection (infection in groin)
Renal failure (kidney dysfunction)

50-59:

Blood pressure decreased
Aortic aneurysm (enlargement of an aortic artery caused by a weakening of the artery wall)
Behcet's syndrome (involves inflammation of the blood vessels)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colitis (inflammation of colon)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Intestinal polyp (small growths in the bowel with the potential for further growth)
Pulmonary mass
Renal cyst (kidney cyst)
Renal disorder (kidney disease)

60+:

Wound complication
Application site erythema (redness of the skin at application site)
Diastolic dysfunction
Drug ineffective
Dry gangrene (diminished blood supply due to vascular problems)
Ear infection
Foot amputation (loss of foot)
Gangrene (body tissue dies)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hyperkalaemia (damage to or disease of the kidney)

What are the existing conditions these people have? *

Pain: 16 people, 50.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 34.38%
Wound: 10 people, 31.25%
Constipation: 9 people, 28.12%
Diabetes: 9 people, 28.12%
Hypersensitivity: 8 people, 25.00%
High Blood Cholesterol: 8 people, 25.00%
Muscle Spasms (muscle contraction): 8 people, 25.00%
High Blood Pressure: 7 people, 21.88%
Faeces Hard: 6 people, 18.75%

* Approximation only. Some reports may have incomplete information.

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