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Santyl and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Santyl (collagenase) and Fentanyl (fentanyl citrate). Common drug interactions include dyspnoea among females and platelet count decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Santyl and Fentanyl. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Santyl?

Santyl has active ingredients of collagenase. eHealthMe is studying from 1,479 Santyl users. Check the latest studies of Santyl.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Aug, 08, 2026

20 people who take Santyl and Fentanyl together, and have interactions are studied.

Santyl and Fentanyl drug interactions.

What are the common drug interactions of Santyl and Fentanyl, by gender? *:

female:

  1. Dyspnoea (difficult or laboured respiration)
  2. Death
  3. Burkholderia test positive
  4. Cough
  5. Diarrhoea
  6. Back injury
  7. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  8. Burning sensation
  9. Crying
  10. Fall

male:

  1. Platelet count decreased
  2. Ascites (accumulation of fluid in the abdominal cavity)
  3. Pneumonia klebsiella (pneumonia caused by bacteria klebsiella)
  4. Shunt stenosis (narrowing of shunt)
  5. Skin necrosis (skin damage)
  6. Urinary tract infection
  7. Death
  8. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  9. Burkholderia test positive
  10. Respiratory rate decreased (less breathing rate/min)

What are the common drug interactions of Santyl and Fentanyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Blood urine present
  2. Diarrhoea
  3. Eye inflammation
  4. Periorbital cellulitis (inflammation and infection of the eyelid and the skin surrounding the eye)
  5. Platelet count decreased
  6. Weight decreased
  7. White blood cell count decreased
  8. Ascites (accumulation of fluid in the abdominal cavity)
  9. Cholangitis sclerosing (infection and obstruction of bile duct)
  10. Pleural effusion (water on the lungs)

40-49:

  1. Renal tubular necrosis (death of kidney tubules)

50-59:

  1. Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
  2. Burning sensation
  3. Crying
  4. Rash erythematous (redness of the skin)
  5. Scab (a hard coating on the skin formed during the wound healing)
  6. Suicidal ideation
  7. Vasculitis (inflammation of a blood vessel or blood vessels)
  8. Wound necrosis (damaged cell of wound)

60+:

  1. Death
  2. Acute myocardial infarction (acute heart attack)
  3. Hypernatraemia (an abnormally high plasma concentration of sodium ions)
  4. Hypopnoea (decrease in the breathing rate)
  5. Hypotension (abnormally low blood pressure)
  6. Insomnia (sleeplessness)
  7. Lethargy (tiredness)
  8. Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
  9. Metastases to adrenals (cancer spreads to adrenal gland of kidney)
  10. Metastases to chest wall (cancer spreads to chest wall)

What are the existing conditions these people have? *

  1. Nausea (feeling of having an urge to vomit): 4 people, 20.00%
  2. Pulmonary Hypertension (increase in blood pressure in the lung artery): 3 people, 15.00%
  3. Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 15.00%
  4. Nausea And Vomiting: 3 people, 15.00%
  5. Wound: 2 people, 10.00%
  6. Depression: 2 people, 10.00%
  7. High Blood Pressure: 2 people, 10.00%
  8. Multiple Myeloma (cancer of the plasma cells): 2 people, 10.00%
  9. Neoplasm Malignant (cancer tumour): 2 people, 10.00%
  10. Pharyngitis (inflammation of the pharynx, causing a sore throat): 2 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Santyl and Fentanyl?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Santyl and Fentanyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Santyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Fentanyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Santyl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fentanyl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on collagenase and fentanyl citrate (the active ingredients of Santyl and Fentanyl, respectively), and Santyl and Fentanyl (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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