Saphris and Melatonin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Saphris (asenapine maleate) and Melatonin (melatonin). Common drug interactions include depression among females and blood pressure increased among males.

The phase IV clinical study analyzes what interactions people have when they take Saphris and Melatonin. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Saphris?

Saphris has active ingredients of asenapine maleate. It is often used in bipolar i disorder. eHealthMe is studying from 8,688 Saphris users. Check the latest studies of Saphris.

What is Melatonin?

Melatonin has active ingredients of melatonin. It is often used in insomnia. eHealthMe is studying from 56,212 Melatonin users. Check the latest studies of Melatonin.

On Jul, 13, 2026

48 people who take Saphris and Melatonin together, and have interactions are studied.

Saphris and Melatonin drug interactions.

What are the common drug interactions of Saphris and Melatonin, by gender? *:

female:

Depression
Dry mouth
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Eye disorder
Furuncle (infection of the hair follicle)
Glossodynia (a burning or painful sensation in the tongue)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Headache (pain in head)
Hereditary angioedema (recurrent episodes of severe swelling)
Hostility

male:

Blood pressure increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Drug level decreased
Mania (a state of abnormally elevated or irritable mood)
Rash
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Decreased appetite
Drug level below therapeutic
Emotional disorder
Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Saphris and Melatonin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Emotional disorder
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Pyrexia (fever)
White blood cell count increased
Blood prolactin increased
Glossodynia (a burning or painful sensation in the tongue)
Cough
Decreased appetite
Drug level below therapeutic

20-29:

Wound infection staphylococcal

30-39:

Adverse drug reaction
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Eye disorder
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Metamorphopsia (a type of distorted vision in which a grid of straight lines appears wavy and parts of the grid may appear blank)

40-49:

Gastrointestinal inflammation (inflammation of stomach and intestine)
Liver disorder (liver diseases)
Weight increased
Asthenia (weakness)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Depression
Dizziness postural
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Poor venous access

50-59:

Middle ear effusion (fluid in middle ear)
Pyrexia (fever)
Sinus disorder (disease of sinus)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Upper respiratory tract infection
Back disorder
Cellulitis (infection under the skin)
Rash
Hospitalisation

60+:

Drug ineffective
Nausea (feeling of having an urge to vomit)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting psychogenic
Abdominal pain upper
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 10 people, 20.83%
Stress And Anxiety: 7 people, 14.58%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 12.50%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 12.50%
Sleep Disorder: 5 people, 10.42%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.33%
Depression: 4 people, 8.33%
Affective Disorder (mental disorder): 4 people, 8.33%
Tardive Dyskinesia (a disorder that involves involuntary movements): 3 people, 6.25%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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