Sarafem and Singulair drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sarafem (fluoxetine hydrochloride) and Singulair (montelukast sodium). Common drug interactions include hiatus hernia among females.

The phase IV clinical study analyzes what interactions people have when they take Sarafem and Singulair. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Sarafem?

Sarafem has active ingredients of fluoxetine hydrochloride. It is often used in premenstrual dysphoric disorder. eHealthMe is studying from 372 Sarafem users. Check the latest studies of Sarafem.

What is Singulair?

Singulair has active ingredients of montelukast sodium. It is often used in asthma. eHealthMe is studying from 129,752 Singulair users. Check the latest studies of Singulair.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

11 people who take Sarafem and Singulair together, and have interactions are studied.

Sarafem and Singulair drug interactions.

What are the common drug interactions of Sarafem and Singulair, by gender? *:

female:

Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Obstruction gastric (obstruction in stomach)
Deafness
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dysphagia (a condition in which swallowing is difficult or painful)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Menstrual disorder (disease of menstrual cycle)
Migraine (headache)
Nerve injury
Pulmonary embolism (blockage of the main artery of the lung)

male:

n/a

What are the common drug interactions of Sarafem and Singulair, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Migraine (headache)
Nerve injury
Vocal cord thickening
Deafness
Menstrual disorder (disease of menstrual cycle)

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Drug ineffective
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Gastric bypass
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Obstruction gastric (obstruction in stomach)

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 36.36%
Mood Swings (an extreme or rapid change in mood): 1 person, 9.09%
Menopausal Symptoms: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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