Savella and Cimzia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Cimzia (certolizumab pegol). Common drug interactions include arthralgia among females and knee arthroplasty among males.

The phase IV clinical study analyzes what interactions people have when they take Savella and Cimzia. It is created by eHealthMe based on reports of 47 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Cimzia?

Cimzia has active ingredients of certolizumab pegol. It is often used in rheumatoid arthritis. eHealthMe is studying from 106,745 Cimzia users. Check the latest studies of Cimzia.

On Aug, 01, 2026

47 people who take Savella and Cimzia together, and have interactions are studied.

What are the common drug interactions of Savella and Cimzia, by gender? *:

female:

Arthralgia (joint pain)
Asthenia (weakness)
Bacterial infection
Chest pain
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Drug hypersensitivity
Dry mouth
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Haemorrhage (bleeding)

male:

Knee arthroplasty
Post procedural infection
Suicidal ideation

What are the common drug interactions of Savella and Cimzia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Dizziness
Dyspnoea (difficult or laboured respiration)
Flushing (the warm, red condition of human skin)
Hypoaesthesia (reduced sense of touch or sensation)
Sensation of foreign body
Throat tightness
Arthralgia (joint pain)
Pain in extremity

50-59:

Diarrhoea
Injection site discolouration
Injection site pain
Photosensitivity reaction
Psoriasis (immune-mediated disease that affects the skin)
Rash erythematous (redness of the skin)
Sinusitis (inflammation of sinus)
Drug ineffective
Arthralgia (joint pain)
Chest wall mass

60+:

Asthenia (weakness)
Cough
Herpes zoster
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Dry eye (lack of adequate tears)
Eye pain

What are the existing conditions these people have? *

Pain: 9 people, 19.15%
Stress And Anxiety: 8 people, 17.02%
Sleep Disorder: 7 people, 14.89%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 14.89%
Ankylosing Spondylitis (type of arthritis affecting the spine): 5 people, 10.64%
Neuropathy Peripheral (surface nerve damage): 5 people, 10.64%
High Blood Cholesterol: 4 people, 8.51%
Muscle Spasms (muscle contraction): 4 people, 8.51%
Oral Candidiasis (fungal infection of mouth): 3 people, 6.38%
Nosebleed (bleeding from nose): 3 people, 6.38%

* Approximation only. Some reports may have incomplete information.

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