Savella and Hydrocodone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Hydrocodone (hydrocodone bitartrate; ibuprofen). Common drug interactions include chronic kidney disease among females and cellulitis among males.

The phase IV clinical study analyzes what interactions people have when they take Savella and Hydrocodone. It is created by eHealthMe based on reports of 31 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Hydrocodone?

Hydrocodone has active ingredients of hydrocodone bitartrate; ibuprofen. eHealthMe is studying from 13,115 Hydrocodone users. Check the latest studies of Hydrocodone.

On Jul, 16, 2026

31 people who take Savella and Hydrocodone together, and have interactions are studied.

Savella and Hydrocodone drug interactions.

What are the common drug interactions of Savella and Hydrocodone, by gender? *:

female:

Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)
Dizziness
Eyelid ptosis (falling of the upper or lower eyelid)
Herpes simplex (herpes simplex is a common viral infection)
Injection site discolouration
Psoriasis (immune-mediated disease that affects the skin)
Renal failure (kidney dysfunction)
Sinusitis (inflammation of sinus)
Breast cancer

male:

Cellulitis (infection under the skin)
Cough
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Myoclonic epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs)
Nasopharyngitis (inflammation of the nasopharynx)
Neuropathy peripheral (surface nerve damage)
Oropharyngeal pain
Weight decreased

What are the common drug interactions of Savella and Hydrocodone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Chronic kidney disease
Gastric bypass
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Renal failure (kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)

50-59:

Dizziness
Injection site discolouration
Psoriasis (immune-mediated disease that affects the skin)
Sinusitis (inflammation of sinus)
Chest wall mass
Dry throat
Herpes simplex (herpes simplex is a common viral infection)
Injection site swelling
Skin discolouration (change of skin colour)
Syncope (loss of consciousness with an inability to maintain postural tone)

60+:

Neuropathy peripheral (surface nerve damage)
Breast cancer
Limb injury
Lower limb fracture
Memory impairment
Muscular weakness (muscle weakness)
Myoclonic epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs)
Nausea (feeling of having an urge to vomit)
Nephrogenic anaemia (anaemia due to kidney disease)
Neuralgia (pain in one or more nerves)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 38.71%
Pain: 9 people, 29.03%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 25.81%
Depression: 7 people, 22.58%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 19.35%
Stress And Anxiety: 6 people, 19.35%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 16.13%
Asthma: 4 people, 12.90%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 9.68%
Chest Pain: 3 people, 9.68%

* Approximation only. Some reports may have incomplete information.

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