Savella and Hydroxyzine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Hydroxyzine hydrochloride (hydroxyzine hydrochloride). Common drug interactions include dry eye among females and anxiety disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Savella and Hydroxyzine hydrochloride. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Hydroxyzine hydrochloride?

Hydroxyzine hydrochloride has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 10,486 Hydroxyzine hydrochloride users. Check the latest studies of Hydroxyzine hydrochloride.

On Jul, 09, 2026

24 people who take Savella and Hydroxyzine hydrochloride together, and have interactions are studied.

Savella and Hydroxyzine hydrochloride drug interactions.

What are the common drug interactions of Savella and Hydroxyzine Hydrochloride, by gender? *:

female:

Dry eye (lack of adequate tears)
Inflammation
Nausea (feeling of having an urge to vomit)
Pain in extremity
Dizziness
Drug ineffective
Injury
Intervertebral disc protrusion (spinal disc protrusion)
Staphylococcal infection (an infection with staphylococcus bacteria)
Back pain

male:

Anxiety disorder
Dizziness
Dyspnoea (difficult or laboured respiration)
Feeling drunk
Hypervigilance
Skin burning sensation
Skin tightness
Somnolence (a state of near-sleep, a strong desire for sleep)
Vertigo

What are the common drug interactions of Savella and Hydroxyzine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Angioedema (rapid swelling of the dermis)
Aphthous ulcer (mouth ulcer)
Bone pain
Headache (pain in head)
Kidney infection
Nausea (feeling of having an urge to vomit)
Oral discomfort (pain or irritation in mouth)
Pain in extremity
Abnormal behaviour
Allergy to metals

30-39:

n/a

40-49:

Dry eye (lack of adequate tears)
Age-related macular degeneration
Arthralgia (joint pain)
Back pain
Bone erosion
Hypoaesthesia (reduced sense of touch or sensation)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Joint crepitation
Joint stiffness
Joint warmth

50-59:

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Renal failure (kidney dysfunction)
Surgery
Angioedema (rapid swelling of the dermis)
Drug hypersensitivity
Chronic kidney disease
Drug ineffective
Joint swelling
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

60+:

Age-related macular degeneration
Retinal pigmentation (pigmentation of retina)
Chronic kidney disease
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 29.17%
Muscle Spasms (muscle contraction): 6 people, 25.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 20.83%
Multiple Allergies (allergy to multiple agents): 4 people, 16.67%
Cystitis Interstitial (unknown cause characterized by bladder pain): 4 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
Back Pain: 4 people, 16.67%
Sleep Disorder: 4 people, 16.67%
Restless Leg Syndrome (a powerful urge to move your legs): 4 people, 16.67%
Raynaud's Phenomenon (discoloration of the fingers, toes, and occasionally other areas): 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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