Savella and Kadian drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Kadian (morphine sulfate). Common drug interactions include arthritis among females and drug hypersensitivity among males.

The phase IV clinical study analyzes what interactions people have when they take Savella and Kadian. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Kadian?

Kadian has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 23,045 Kadian users. Check the latest studies of Kadian.

On Jul, 28, 2026

18 people who take Savella and Kadian together, and have interactions are studied.

What are the common drug interactions of Savella and Kadian, by gender? *:

female:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chronic kidney disease
Cold sweat
Colour blindness acquired (development of colour vision disability due to damage to eye)
Decreased appetite
Diarrhoea
Discomfort
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea exertional (breathlessness or shortness of breath)
Fluid retention (an abnormal accumulation of fluid in the blood)

male:

Drug hypersensitivity
Pneumonia

What are the common drug interactions of Savella and Kadian, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Headache (pain in head)
Flushing (the warm, red condition of human skin)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Chest pain
Chronic kidney disease
Cold sweat
Decreased appetite
Drug ineffective
Dyspnoea exertional (breathlessness or shortness of breath)

50-59:

Peripheral swelling
Chest pain
Dyspnoea (difficult or laboured respiration)
Abdominal distension
Fluid retention (an abnormal accumulation of fluid in the blood)
Joint swelling

60+:

Drug ineffective
Colour blindness acquired (development of colour vision disability due to damage to eye)
Discomfort
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 22.22%
Drowsiness: 2 people, 11.11%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 5.56%
Muscle Aches (muscle pain): 1 person, 5.56%
Back Pain: 1 person, 5.56%
Blood Pressure Abnormal: 1 person, 5.56%
Burning Sensation: 1 person, 5.56%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.56%
Headache (pain in head): 1 person, 5.56%
Migraine (headache): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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