Savella and Relafen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Relafen (nabumetone). Common drug interactions include flushing among females.

The phase IV clinical study analyzes what interactions people have when they take Savella and Relafen. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Relafen?

Relafen has active ingredients of nabumetone. It is often used in arthritis. eHealthMe is studying from 6,243 Relafen users. Check the latest studies of Relafen.

On Jul, 27, 2026

14 people who take Savella and Relafen together, and have interactions are studied.

What are the common drug interactions of Savella and Relafen, by gender? *:

female:

Flushing (the warm, red condition of human skin)
Drug hypersensitivity
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Rectal haemorrhage (bleeding from anus)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Affect lability (emotional incontinence)
Anaemia (lack of blood)
Ankle fracture
Anosognosia (ignorance of the presence of disease)

male:

n/a

What are the common drug interactions of Savella and Relafen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Application site rash
Dry mouth
Dyspnoea (difficult or laboured respiration)
Feeling hot
Glossitis (infection of tongue with soreness)
Glossodynia (a burning or painful sensation in the tongue)
Hyperhidrosis (abnormally increased sweating)
Muscle spasms (muscle contraction)
Rash
Wheezing (a high-pitched whistling sound made while you breath)

50-59:

Drug hypersensitivity

60+:

Renal failure (kidney dysfunction)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Bruxism (habitual grinding of the teeth, typically during sleep)
Burning sensation
Butterfly rash
Cataract (clouding of the lens inside the eye)
Choking (mechanical obstruction of the flow of air from the environment into the lungs)
Chorea (abnormal involuntary movement disorder)
Chronic kidney disease
Colonic polyp (extra part of colon tissue grow in intestine)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 14.29%
Pain: 2 people, 14.29%
Insomnia (sleeplessness): 2 people, 14.29%
High Blood Cholesterol: 2 people, 14.29%
Depression: 2 people, 14.29%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 1 person, 7.14%
Back Pain: 1 person, 7.14%
Bruxism (habitual grinding of the teeth, typically during sleep): 1 person, 7.14%
Cardiac Disorder: 1 person, 7.14%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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