Savella and Valacyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Valacyclovir (valacyclovir hydrochloride). Common drug interactions include drug ineffective among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Savella and Valacyclovir. It is created by eHealthMe based on reports of 82 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

On Jul, 09, 2026

82 people who take Savella and Valacyclovir together, and have interactions are studied.

Savella and Valacyclovir drug interactions.

What are the common drug interactions of Savella and Valacyclovir, by gender? *:

female:

Drug ineffective
Upper-airway cough syndrome
Dehydration (dryness resulting from the removal of water)
Hepatitis c
Hip fracture
Muscular weakness (muscle weakness)
Pancreatitis (inflammation of pancreas)
Arthralgia (joint pain)
Osteoporosis (bones weak and more likely to break)
Pain in extremity

male:

Anxiety
Erectile dysfunction
Sleep disorder
Testicular pain (pain in testes)
Pneumonia
Thrombosis (formation of a blood clot inside a blood vessel)

What are the common drug interactions of Savella and Valacyclovir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Nasal disorder (diseases of nose)
Nightmare (unpleasant dream)
Rhinitis allergic (inflammation of the nasal airways due to allergy)
Sinusitis (inflammation of sinus)
Sleep terror (felling of terror in sleep)
Substance abuse
Syncope (loss of consciousness with an inability to maintain postural tone)
Urticaria (rash of round, red welts on the skin that itch intensely)
Vomiting
Abnormal behaviour

30-39:

Cough
Fatigue (feeling of tiredness)
Upper-airway cough syndrome
Dyspepsia (indigestion)
Psoriasis (immune-mediated disease that affects the skin)

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Asthenia (weakness)
Dental caries
Emotional distress
Headache (pain in head)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Myalgia (muscle pain)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)

50-59:

Drug ineffective
Fall
Candidiasis (candidiasis or thrush is a fungal infection)
Onychomycosis (fungal infection of the nail)
Urinary tract infection
Vitamin d decreased
Stomatitis (inflammation of mucous membrane of mouth)
Back disorder
Bladder prolapse (bulging of one or more of the pelvic organs into the vagina)
Blood pressure decreased

60+:

Anxiety
Dizziness
Vomiting
Balance disorder
Injection site irritation
Injection site pruritus (severe itching at injection site)
Injection site swelling
Sepsis (a severe blood infection that can lead to organ failure and death)
Erectile dysfunction
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 30 people, 36.59%
Pain: 11 people, 13.41%
High Blood Pressure: 10 people, 12.20%
Depression: 9 people, 10.98%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 10.98%
Stress And Anxiety: 8 people, 9.76%
Migraine (headache): 8 people, 9.76%
Neuralgia (pain in one or more nerves): 8 people, 9.76%
Nausea (feeling of having an urge to vomit): 8 people, 9.76%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 7 people, 8.54%

* Approximation only. Some reports may have incomplete information.

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