Sectral and Depakote drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sectral (acebutolol hydrochloride) and Depakote (divalproex sodium). Common drug interactions include loss of consciousness among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Sectral and Depakote. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Sectral?

Sectral has active ingredients of acebutolol hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 3,548 Sectral users. Check the latest studies of Sectral.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

17 people who take Sectral and Depakote together, and have interactions are studied.

What are the common drug interactions of Sectral and Depakote, by gender? *:

female:

Loss of consciousness
Chest pain
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Biliary tract disorder
Blood cholesterol increased
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Dental caries
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypokalaemia (low potassium)

male:

Fall
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Atelectasis (partial or complete collapse of the lung)
Balance disorder
Blood albumin decreased
Blood glucose increased
Bone disorder
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Cardiac failure congestive
Colonic polyp (extra part of colon tissue grow in intestine)

What are the common drug interactions of Sectral and Depakote, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Atrial tachycardia (rhythm disturbance that arises in the atria)
Bundle branch block left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

50-59:

n/a

60+:

Fall
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Anaemia (lack of blood)
Atelectasis (partial or complete collapse of the lung)
Balance disorder
Blood albumin decreased
Blood glucose increased
Bone disorder
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)

What are the existing conditions these people have? *

Stress And Anxiety: 3 people, 17.65%
Ischaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease): 3 people, 17.65%
Insomnia (sleeplessness): 3 people, 17.65%
Depression: 3 people, 17.65%
Osteoporosis (bones weak and more likely to break): 2 people, 11.76%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.88%
Intervertebral Disc Degeneration (spinal disc degeneration): 1 person, 5.88%
Ill-Defined Disorder: 1 person, 5.88%
Hyperuricaemia (level of uric acid in the blood that is abnormally high): 1 person, 5.88%
High Blood Cholesterol: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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