Sectral and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Sectral (acebutolol hydrochloride) and Zide (hydrochlorothiazide). Common drug interactions include tardive dyskinesia among females and blood creatine phosphokinase increased among males.

The phase IV clinical study analyzes what interactions people have when they take Sectral and Zide. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Sectral?

Sectral has active ingredients of acebutolol hydrochloride. It is often used in high blood pressure. eHealthMe is studying from 3,548 Sectral users. Check the latest studies of Sectral.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 05, 2026

53 people who take Sectral and Zide together, and have interactions are studied.

What are the common drug interactions of Sectral and Zide, by gender? *:

female:

Tardive dyskinesia (a disorder that involves involuntary movements)
Weight increased
Abdominal pain upper
Abnormal dreams
Agoraphobia (extreme or irrational fear of crowded spaces or enclosed public places)
Alopecia (absence of hair from areas of the body)
Anger
Angina pectoris (chest pain due to ischemia of the heart muscle)
Aortic valve incompetence
Arthritis (form of joint disorder that involves inflammation of one or more joints)

male:

Blood creatine phosphokinase increased
Injury
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Confusional state
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Depression
Dizziness
Dysarthria (speech disorder)
Dyspnoea (difficult or laboured respiration)

What are the common drug interactions of Sectral and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Chest pain
Pain

50-59:

Incoherent (talking in a confused and unclear way)
Injury
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Loss of consciousness
Paralysis
Urinary tract infection
Visual disturbance
Amaurosis (partial or total blindness without visible change in the eye)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Aphasia (damage to the parts of the brain that control language)

60+:

Cellulitis (infection under the skin)
Dyspnoea (difficult or laboured respiration)
Back pain
Confusional state
Constipation
Dementia alzheimer's type (loss of mental ability with alzheimer's symptom)
Dizziness
Frequent bowel movements
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Lung neoplasm malignant (cancer tumour of lung)

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 11.32%
Osteoporosis (bones weak and more likely to break): 4 people, 7.55%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 5.66%

* Approximation only. Some reports may have incomplete information.

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