Selenium sulfide and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Selenium sulfide (selenium sulfide) and Diphen (diphenhydramine hydrochloride). Common drug interactions include abdominal pain upper among females and retinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Selenium sulfide and Diphen. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Selenium sulfide?

Selenium sulfide has active ingredients of selenium sulfide. It is often used in seborrheic dermatitis. eHealthMe is studying from 854 Selenium sulfide users. Check the latest studies of Selenium sulfide.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 17, 2026

49 people who take Selenium sulfide and Diphen together, and have interactions are studied.

Selenium sulfide and Diphen drug interactions.

What are the common drug interactions of Selenium Sulfide and Diphen, by gender? *:

female:

Abdominal pain upper
Vomiting
Back pain
Fatigue (feeling of tiredness)
Neck pain
Rash pruritic (redness with itching)
Thrombosis (formation of a blood clot inside a blood vessel)
Urinary tract infection
Gun shot wound
Infusion site pruritus (severe itching at infusion site)

male:

Retinal haemorrhage (bleeding from retina)
Chronic kidney disease
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Renal impairment (severely reduced kidney function)
Retinal pigment epithelial tear (pigment epithelial tear of retina)
Visual acuity reduced (reduced clearness of vision)
Vitreous detachment (a condition of the eye in which the vitreous humour separates from the retina)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased

What are the common drug interactions of Selenium Sulfide and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Infusion site erythema (reddening of the skin at infusion site)
Rash erythematous (redness of the skin)

30-39:

n/a

40-49:

Chronic kidney disease
Osteonecrosis (death of bone)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Bone density decreased
Emotional distress
Hip arthroplasty
Pain
Renal impairment (severely reduced kidney function)

50-59:

Neutropenia (an abnormally low number of neutrophils)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Connective tissue disorder (any disease that has the connective tissues of the body)
Faeces discoloured
Gastric ulcer (stomach ulcer)
Gastritis (inflammation of stomach)
Haematemesis (vomiting of blood)
Impaired gastric emptying
Melaena (the passage of black, tarry stools)

60+:

Retinal haemorrhage (bleeding from retina)
Cutis laxa (connective tissue disorder in which the skin lacks elasticity and hangs in loose folds)
Anaemia (lack of blood)
Blood potassium increased
Constipation
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Leukopenia (less number of white blood cells in blood)
Local swelling (swelling at the site of some application of substance or injury)
Presyncope
Pruritus (severe itching of the skin)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 14 people, 28.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 8 people, 16.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 16.33%
Constipation: 5 people, 10.20%
High Blood Pressure: 4 people, 8.16%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.16%
High Blood Cholesterol: 4 people, 8.16%
Primary Immunodeficiency Syndrome: 4 people, 8.16%
Allergic Rhinitis: 4 people, 8.16%
Pain: 4 people, 8.16%

* Approximation only. Some reports may have incomplete information.

Do you take Selenium sulfide and Diphen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously