Senna and Enablex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Senna (senna) and Enablex (darifenacin hydrobromide). Common drug interactions include death among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Senna and Enablex. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

On Jul, 09, 2026

13 people who take Senna and Enablex together, and have interactions are studied.

What are the common drug interactions of Senna and Enablex, by gender? *:

female:

Death
Fatigue (feeling of tiredness)
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Hand fracture
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)

male:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Atrophy (wasting away of a part of the body)
Haemoglobin decreased
Hyperglycaemia (high blood sugar)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Lethargy (tiredness)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Pain
Pancreatic carcinoma (pancreatic cancer)
Pleural effusion (water on the lungs)

What are the common drug interactions of Senna and Enablex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease

50-59:

Atrophy (wasting away of a part of the body)
Blood calcium decreased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Colitis ischaemic (due to infection of intestine impaired blood supply to colon)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematocrit decreased
Haemoglobin decreased
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Nervous system disorder (a general class of medical conditions affecting the nervous system)

60+:

Death
Alopecia (absence of hair from areas of the body)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lethargy (tiredness)
Lower gastrointestinal haemorrhage (bleeding in the large intestine, rectum, or anus is called lower gi bleeding)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pain
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Pyuria (a condition of urine containing pus)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)

What are the existing conditions these people have? *

Pain: 4 people, 30.77%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 23.08%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 23.08%
Infection: 2 people, 15.38%
Insomnia (sleeplessness): 2 people, 15.38%
Nausea And Vomiting: 2 people, 15.38%
Depression: 2 people, 15.38%
High Blood Cholesterol: 2 people, 15.38%
Bipolar Disorder (mood disorder): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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