Senna and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Senna (senna) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include hallucination, auditory among females and urinary tract infection among males.

The phase IV clinical study analyzes what interactions people have when they take Senna and Excedrin. It is created by eHealthMe based on reports of 89 people who take the same drugs from the FDA, and is updated regularly.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

89 people who take Senna and Excedrin together, and have interactions are studied.

What are the common drug interactions of Senna and Excedrin, by gender? *:

female:

Hallucination, auditory (perceiving sounds without auditory stimulus)
Heart rate increased
Localised infection (infection at the single location)
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Nausea (feeling of having an urge to vomit)
Bowel movement irregularity
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Abdominal pain upper
Altered state of consciousness (altered state of mind)
Weight decreased

male:

Urinary tract infection
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)
Renal failure (kidney dysfunction)
Respiratory failure (inadequate gas exchange by the respiratory system)
Anxiety
Arachnoiditis (neuropathic disease caused by inflammation of the arachnoid)
Arteriovenous fistula
Blood pressure diastolic decreased
Blood pressure diastolic increased

What are the common drug interactions of Senna and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Pneumonia

20-29:

Abdominal discomfort
Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Blood potassium decreased
Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea

30-39:

Altered state of consciousness (altered state of mind)
Unresponsive to stimuli
Decreased appetite
Device dislocation
Weight decreased
Acute hepatic failure
Anxiety
Chest pain
Dyspnoea (difficult or laboured respiration)
Fear

40-49:

Chronic kidney disease
Altered state of consciousness (altered state of mind)
Crepitations (noises are produced by the rubbing of parts one against the other)
Discomfort
Dyspnoea (difficult or laboured respiration)
Irritability
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Rales (an abnormal respiratory sound characterized by fine crackles)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary tract infection

50-59:

Asthenia (weakness)
Back pain
Blood pressure diastolic decreased
Blood pressure diastolic increased
Blood pressure systolic increased
Bradycardia (abnormally slow heart action)
Cataract (clouding of the lens inside the eye)
Cervical cord compression (compression of spinal cord at site of cervical vertebrae)
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Chills (felling of cold)

60+:

Urinary tract infection
Malaise (a feeling of general discomfort or uneasiness)
Fall
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Hallucination, auditory (perceiving sounds without auditory stimulus)
Heart rate increased
Localised infection (infection at the single location)
Parkinsonism (degenerative disorder of the central nervous system characterized by tremor and impaired muscular coordination)
Pneumonia

What are the existing conditions these people have? *

Pain: 26 people, 29.21%
Hallucinations (sensations that appear real but are created by your mind): 20 people, 22.47%
Delusion (a false belief or opinion): 16 people, 17.98%
Migraine (headache): 16 people, 17.98%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 16.85%
High Blood Pressure: 15 people, 16.85%
Nausea (feeling of having an urge to vomit): 11 people, 12.36%
Hypersensitivity: 11 people, 12.36%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 9 people, 10.11%
Parkinson's Disease: 9 people, 10.11%

* Approximation only. Some reports may have incomplete information.

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