Senna and Ozempic drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Senna (senna) and Ozempic (semaglutide). Common drug interactions include eye infection among females and ischaemic stroke among males.

The phase IV clinical study analyzes what interactions people have when they take Senna and Ozempic. It is created by eHealthMe based on reports of 67 people who take the same drugs from the FDA, and is updated regularly.

What is Senna?

Senna has active ingredients of senna. It is often used in constipation. eHealthMe is studying from 37,302 Senna users. Check the latest studies of Senna.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,762 Ozempic users. Check the latest studies of Ozempic.

On Aug, 13, 2026

67 people who take Senna and Ozempic together, and have interactions are studied.

What are the common drug interactions of Senna and Ozempic, by gender? *:

female:

Eye infection
Fungal infection
Hyperaesthesia
Infusion site haemorrhage (bleeding from infusion site)
Infusion site pain
Insomnia (sleeplessness)
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Phlebitis (inflammation of the walls of a vein)
Post procedural infection

male:

Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Hospitalisation
Abscess limb (limb infection)
Asthenia (weakness)
Cellulitis (infection under the skin)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chills (felling of cold)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Colon gangrene (colon tissue dies)

What are the common drug interactions of Senna and Ozempic, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)
White blood cell count increased

40-49:

Cellulitis of male external genital organ (infection of male genitals soft tissue)
Chronic kidney disease
Colon gangrene (colon tissue dies)
Deformity (disfigurement)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Infected dermal cyst
Necrosis (the death of body tissue)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nerve injury
Pain

50-59:

Hospitalisation
Abdominal abscess (collection of pus in abdomen)
Abdominal discomfort
Fatigue (feeling of tiredness)
International normalised ratio increased
Abscess limb (limb infection)
Acute respiratory failure
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Asthenia (weakness)
Chills (felling of cold)

60+:

Acute sinusitis
Appendicitis (inflammation of the appendix)
Injection site pain
Intra-abdominal haemorrhage (intra-abdominal bleeding)
Iron deficiency anaemia
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Pain in extremity
Sinusitis (inflammation of sinus)
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other)
Urticaria (rash of round, red welts on the skin that itch intensely)

What are the existing conditions these people have? *

Type 2 Diabetes: 19 people, 28.36%
High Blood Pressure: 18 people, 26.87%
Hyperlipidaemia (presence of excess lipids in the blood): 16 people, 23.88%
Pain In Extremity: 13 people, 19.40%
Joint Pain: 13 people, 19.40%
Pain: 12 people, 17.91%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 16.42%
Diabetes: 10 people, 14.93%
Immunodeficiency Common Variable: 10 people, 14.93%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 14.93%

* Approximation only. Some reports may have incomplete information.

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